TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study

被引：1

作者：

Cruciat, Gheorghe ^{[1
]}

Florian, Andreea Roxana ^{[1
]}

Chaikh-Sulaiman, Mariam-Suzana ^{[1
]}

Staicu, Adelina ^{[1
]}

Caracostea, Gabriela Valentina ^{[1
]}

Procopciuc, Lucia Maria ^{[2
]}

Stamatian, Florin ^{[3
]}

Muresan, Daniel ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Mother & Child Dept, Obstet & Gynecol 1, Cluj Napoca 400347, Romania

[2] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Med Biochem, Cluj Napoca 400347, Romania

[3] Imogen Clin Res Ctr, Cluj Napoca 400347, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 07期

关键词：

gestational diabetes mellitus; rs7903146 (C/T) polymorphism; fetal macrosomia; INCREASED RISK; GENE; PREGNANCY; HYPERGLYCEMIA; VARIANTS; ASSOCIATION;

D O I：

10.3390/ijms25074039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gestational diabetes mellitus (GDM) is one of the most frequent predictors of obstetric outcome among Romanian pregnant women. Thus, we aimed to investigate the role of rs7903146 (C/T) TCF7L2 gene polymorphism in the presence of GDM and to evaluate the influence on maternal-fetal outcomes in a cohort of pregnant women from Northern Transylvania. Our prospective case-control study was performed in a tertiary maternity center on 61 patients diagnosed with GDM and 55 normal pregnant patients. The patients were genotyped for rs7903146 (C/T) polymorphism of the TCF7L2 gene using the PCR-RFLP method between 24 and 28 weeks of gestation. The minor T allele was associated with a high risk of developing GDM (OR 1.71 [95% CI 0.82-3.59]) if both heterozygote and homozygote types were considered. Also, a higher risk of developing GDM was observed in homozygous carriers (OR 3.26 [95% CI 1.10-9.68]). Women with the TT genotype were more likely to require insulin therapy during pregnancy than other genotypes with a 5.67-fold increased risk ([1.61-19.97], p = 0.015). TT homozygote type was significantly associated with fetal macrosomia for birth weights greater than the 95th percentile (p = 0.034). The homozygous TT genotype is associated with an increased risk of developing GDM. Also, rs7903146 (C/T) TCF7L2 variant is accompanied by a high probability of developing insulin-dependent gestational diabetes mellitus (ID-GDM). The presence of at least one minor T allele was associated with a higher risk of fetal macrosomia.

引用

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