Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics

被引:5
作者
Zhang, Bin [1 ,2 ]
Yang, Rui [2 ,3 ]
Yu, Hongwei [5 ]
Peng, Yamin [2 ]
Huang, Haoyu [2 ]
Hameed, Meera Moydeen Abdul [4 ]
Wang, Han [5 ]
Zhang, Guixiang [1 ]
EL-Newehy, Mohamed [4 ]
Shen, Mingwu [2 ]
Shi, Xiangyang [2 ,6 ]
Peng, Shaojun [7 ]
机构
[1] Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Radiol, Shanghai 200434, Peoples R China
[2] Donghua Univ, Coll Biol Sci & Med Engn, Shanghai Engn Res Ctr Nanobiomaterials & Regenerat, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China
[3] Kunming Univ Sci & Technol, Med Sch, Kunming 650500, Peoples R China
[4] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
[5] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Radiol, Shanghai 200080, Peoples R China
[6] Univ Madeira, CQM Ctr Quim Madeira, P-9020105 Funchal, Portugal
[7] Beijing Normal Univ, Coll Arts & Sci, Ctr Biol Sci & Technol, Zhuhai 519087, Peoples R China
基金
中国国家自然科学基金;
关键词
MAGNETIC-RESONANCE; CANCER-THERAPY; LUNG METASTASIS; INFLAMMATION; GADOLINIUM; TISSUE;
D O I
10.1039/d4bm00357h
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Developing effective nanomedicines to cross the blood-brain barrier (BBB) for efficient glioma theranostics is still considered to be a challenging task. Here, we describe the development of macrophage membrane (MM)-coated nanoclusters (NCs) of ultrasmall iron oxide nanoparticles (USIO NPs) with dual pH- and reactive oxygen species (ROS)-responsivenesses for magnetic resonance (MR) imaging and chemotherapy/chemodynamic therapy (CDT) of orthotopic glioma. Surface citrate-stabilized USIO NPs were solvothermally synthesized, sequentially modified with ethylenediamine and phenylboronic acid, and cross-linked with gossypol to form gossypol-USIO NCs (G-USIO NCs), which were further coated with MMs. The prepared MM-coated G-USIO NCs (G-USIO@MM NCs) with a mean size of 99.9 nm display tumor microenvironment (TME)-responsive gossypol and Fe release to promote intracellular ROS production and glutathione consumption. With the MM-mediated BBB crossing and glioma targeting, the G-USIO@MM NCs can specifically inhibit orthotopic glioma in vivo through the gossypol-mediated chemotherapy and Fe-mediated CDT. Meanwhile, USIO NPs can be dissociated from the NCs under the TME, thus allowing for effective T1-weighted glioma MR imaging. The developed G-USIO@MM NCs with simple components and drug as a crosslinker are promising for glioma theranostics, and may be extended to tackle other cancer types. Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles can be developed to cross the blood-brain barrier for magnetic resonance imaging and chemo/chemodynamic therapy.
引用
收藏
页码:2705 / 2716
页数:12
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