Antisynthetase syndrome, a rare cause of respiratory failure

被引：0

作者：

Mulder, T. ^{[1
]}

Huijsmans, R. L. N. ^{[1
]}

de Klerk, B. ^{[2
]}

Kamphuis, J. S. ^{[3
]}

Spronk, P. E. ^{[1
,4
]}

机构：

[1] Gelre Hosp, Dept Intens Care, Apeldoorn, Netherlands

[2] Gelre Hosp, Dept Rheumatol, Apeldoorn, Netherlands

[3] Gelre Hosp, Dept Clin Chem & Hematol, Apeldoorn, Netherlands

[4] Expertise Ctr Intens Care Rehabil ExpIRA, Apeldoorn, Netherlands

来源：

NETHERLANDS JOURNAL OF CRITICAL CARE | 2023年 / 31卷 / 01期

关键词：

antisynthetase syndrome; myositis; respiratory failure; INTERSTITIAL LUNG-DISEASE; AUTOANTIBODIES; POLYMYOSITIS; SURVIVAL; COHORT;

D O I：

暂无

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A 72-year-old patient was admitted to the intensive care unit with respiratory failure due to rapidly progressive interstitial lung disease (ILD). All cultures and PCRs focused on ILD were negative and a paraneoplastic phenomenon was deemed unlikely after screening for malignancy. Inflammatory myositis was suspected as the patient also presented fever, progressive pitting oedema and arthritis in both hands and feet. A myositis blot revealed high titres of anti- Jo-1 antibodies: the patient was diagnosed with antisynthetase syndrome and was treated with high-dose corticosteroids, cyclophosphamide and intravenous immunoglobulins with a gradual full recovery. Antisynthetase syndrome should be considered in patients with idiopathic or rapidly progressive ILD.

引用

页码：5 / 8

页数：4

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