The role of ANXA1 in the tumor microenvironment

被引：3
作者：
Li, Lanxin [1 ]
Wang, Baiqi [2 ]
Zhao, Shuang [1 ]
Xiong, Qinglin [1 ]
Cheng, Ailan [1 ]
机构：
[1] Univ South China, Canc Res Inst, Hunan Engn Res Ctr Early Diag & Treatment Liver Ca, Hengyang Med Sch, Hengyang, Peoples R China
[2] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 131卷
基金：
中国国家自然科学基金;
关键词：
AnnexinA1; Tumor microenvironment; Inflammation; Immune; Angiogenesis; CANCER-ASSOCIATED FIBROBLASTS; ANNEXIN A1; GROWTH-FACTOR; MACROPHAGE POLARIZATION; CIRCULATING ANTIBODIES; OXIDATIVE STRESS; DRUG-RESISTANCE; GASTRIC-CANCER; CORE DOMAINS; LUNG-CANCER;
D O I：
10.1016/j.intimp.2024.111854
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Annexin A1 (ANXA1) is widely expressed in a variety of body tissues and cells and is also involved in tumor development through multiple pathways. The invasion, metastasis, and immune escape of tumor cells depend on the interaction between tumor cells and their surrounding environment. Research shows that ANXA1 can act on a variety of cells in the tumor microenvironment (TME), and subsequently affect the proliferation, invasion and metastasis of tumors. This article describes the role of ANXA1 in the various components of the tumor microenvironment and its mechanism of action, as well as the existing clinical treatment measures related to ANXA1. These findings provide insight for the further design of strategies targeting ANXA1 for the diagnosis and treatment of malignant tumors.
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页数：9
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