Use of coronary artery calcium score and coronary CT angiography to guide cardiovascular prevention and treatment

被引：4

作者：

Lima, Maria Rita ^{[1
]}

Lopes, Pedro M. ^{[1
]}

Ferreira, Antonio M. ^{[1
,2
]}

机构：

[1] Ctr Hosp Lisboa Ocidental, Hosp Santa Cruz, Dept Cardiol, Ave Prof Dr Reinaldo dos Santos, P-2790134 Carnaxide, Lisbon, Portugal

[2] Hosp Luz, UNICA Cardiovasc CT & MR Unit, Lisbon, Portugal

来源：

THERAPEUTIC ADVANCES IN CARDIOVASCULAR DISEASE | 2024年 / 18卷

关键词：

atherosclerosis; coronary artery calcium score; coronary artery disease; coronary CT angiography; primary preventive therapy; MYOCARDIAL-INFARCTION; PLAQUE CHARACTERISTICS; COMPUTED-TOMOGRAPHY; PARADIGM REGISTRY; RISK CALCULATORS; STATIN THERAPY; HEART-DISEASE; CHEST-PAIN; ATHEROSCLEROSIS; PROGRESSION;

D O I：

10.1177/17539447241249650

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Currently, cardiovascular risk stratification to guide preventive therapy relies on clinical scores based on cardiovascular risk factors. However, the discriminative power of these scores is relatively modest. The use of coronary artery calcium score (CACS) and coronary CT angiography (CCTA) has surfaced as methods for enhancing the estimation of risk and potentially providing insights for personalized treatment in individual patients. CACS improves overall cardiovascular risk prediction and may be used to improve the yield of statin therapy in primary prevention, and possibly identify patients with a favorable risk/benefit relationship for antiplatelet therapies. CCTA holds promise to guide anti-atherosclerotic therapies and to monitor individual response to these treatments by assessing individual plaque features, quantifying total plaque volume and composition, and assessing peri-coronary adipose tissue. In this review, we aim to summarize current evidence regarding the use of CACS and CCTA for guiding lipid-lowering and antiplatelet therapy and discuss the possibility of using plaque burden and plaque phenotyping to monitor response to anti-atherosclerotic therapies.

引用

页数：13

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