The hot deformation behavior in plane strain compression of the TC21G titanium alloy was investigated in the deformation temperatures ranging from 870℃ to 940℃, the strain rates ranging from 0.1 s-1 to 1 s-1. The microstructures evolution was also analyzed. Meanwhile, the effect of processing parameters on the strain hardening exponent n was analyzed. The results show that, under the condition of a certain strain rate, the flow stress of alloy decreases with the increase of the deformation temperature due to the increase of β phase content. However, in the condition of a certain temperature, the flow stress of alloy increases with the increase of the strain rate, because the velocity of mobile dislocations increases. During deforming in the α+β field, with the increase of the deformation temperature or strain, and the decrease of the strain rate, the globularization degree of the lamellar α phase increases. Based on the microstructure examination, the variation of n values is found to depend on the adiabatic heating effect, dynamic recrystallization (DRX) and dynamic recovery (DRV) of β phase. © 2021, Science Press. All right reserved.