Qualitative analysis on a reaction-diffusion SIS epidemic model with nonlinear incidence and Dirichlet boundary

In this paper, the dynamical behavior in a spatially heterogeneous reaction-diffusion SIS epidemic model with general nonlinear incidence and Dirichlet boundary condition is investigated. The well-posedness of solutions, including the global existence, nonnegativity, ultimate boundedness, as well as the existence of compact global attractor, are first established, then the basic reproduction number R-0 is calculated by defining the next generation operator. Secondly, the threshold dynamics of the model with respect to R-0 are studied. That is, when R-0< 1 the disease -free steady state is globally asymptotically stable, and when R-0 > 1 the model is uniformly persistent and admits one positive steady state, and under some additional conditions the uniqueness of positive steady state is obtained. Furthermore, some interesting properties of R-0 are established, including the calculating formula of R-0, the asymptotic profiles of R-0 with respect to diffusion rate R-0, and the monotonicity of R-0 with diffusion rate d(I )and domain Omega. In addition, the bang-bang-type configuration optimization of R-0 also is obtained. This rare result in diffusive equation reveals that we can control disease diffusion at least at one peak. Finally, the numerical examples and simulations are carried out to illustrate the rationality of open problems proposed in this paper, and explore the influence of spatial heterogeneous environment on the disease spread and make a comparison on dynamics between Dirichlet boundary condition and Neumann boundary condition.