Comparison of clinical and laboratory data of adult patients with cutaneous IgA vasculitis and non-IgA vasculitis

被引：3

作者：

Gambichler, Thilo ^{[1
,2
,3
]}

Bui, Duyen ^{[1
]}

Domin, Belanna ^{[1
]}

Ardabili, Larisa ^{[1
]}

Devrim, Yusa ^{[3
]}

Abu Rached, Nessr ^{[1
]}

Susok, Laura ^{[1
,3
]}

机构：

[1] Ruhr Univ Bochum, Dept Dermatol, Bochum, Germany

[2] Christian Hosp Unna, Dept Dermatol, Unna, Germany

[3] Univ Witten Herdecke, Dept Dermatol, Klinikum Dortmund GmbH, Dortmund, Germany

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2024年 / 49卷 / 08期

关键词：

HENOCH-SCHONLEIN PURPURA; HYPERSENSITIVITY VASCULITIS; LEUKOCYTOCLASTIC VASCULITIS;

D O I：

10.1093/ced/llae062

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Immune complex vasculitides may be subdivided into adult IgA small vessel vasculitis (aIgA-SVV; i.e. adult Henoch-Schonlein purpura) and non-IgA-SVV (hypersensitivity vasculitis, etc.).Objectives To evaluate the clinical and laboratory parameters of inpatients fulfilling the diagnostic criteria for aIgA-SVV and non-IgA-SVV.Methods Twenty-nine adults aged >= 20 years with aIgA-SVV [according to the European League Against Rheumatism/Paediatric Rheumatology International Trials Organisation/Paediatric Rheumatology European Society (EULAR/PRINTO/PRES) criteria] and 53 adults with non-IgA-SVV (according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides) were compared with respect to a variety of clinical and laboratory parameters by uni- and multivariable analyses.Results Compared with patients with aIgA-SVV, the platelet-to-lymphocyte ratio was significantly higher in patients with non-IgA-SVV. Serum C3 levels and mean corpuscular haemoglobin concentration in patients with non-IgA-SVV were significantly lower compared with patients with aIgA-SVV. Proteinuria and haematuria were significantly more common in patients with aIgA SVV, and were significantly correlated with systemic immune-inflammation biomarkers only in patients with aIgA-SVV. In patients with aIgA-SVV, higher lactate dehydrogenase and C-reactive protein were strong independent predictors for the presence of proteinuria and proteinuria. In patients with non-IgA-SVV, female sex was a protective factor for proteinuria, while skin lesions on the upper extremities proved to be a significant independent predictor of haematuria.Conclusions We detected several clinical and laboratory differences between patients with aIgA-SVV and non-IgA-SVV. Distinct predictors for renal involvement were not observed in either group, indicating that aIgA-SVV and non-IgA-SVV are similar conditions but do not appear to represent the same entity. Cutaneous small-vessel vasculitides may be differentiated as IgA and non-IgA-mediated. Adult (a)IgA small-vessel vasculitis (SVV) has rarely been compared with non-IgA SVV. We detected several clinical and laboratory differences between patients with aIgA-SVV and non-IgA-SVV, indicating that both conditions likely do not represent the same entity.

引用

页码：859 / 865

页数：7

共 42 条

[1] Incidence of Leukocytoclastic Vasculitis, 1996 to 2010: A Population-Based Study in Olmsted County, Minnesota [J].