Advanced Glycation End Products and Health: A Systematic Review

被引：17

作者：

Zhu, Jianming ^{[1
,2
]}

Wang, Ziming ^{[1
]}

Lv, Chunyan ^{[1
]}

Li, Mengtian ^{[1
]}

Wang, Kaiyi ^{[1
]}

Chen, Zhencheng ^{[1
]}

机构：

[1] Guilin Univ Elect Technol, Sch Life & Environm Sci, Guilin 541004, Peoples R China

[2] Guilin Univ Elect Technol, Guangxi Key Lab Automat Detecting Technol & Instru, Guilin, Peoples R China

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2024年 / 52卷 / 12期

基金：

中国国家自然科学基金;

关键词：

AGEs; Glycation; Diabetes complications; Pathological mechanisms; Detection methods; N-EPSILON-CARBOXYMETHYLLYSINE; DIABETIC VASCULAR COMPLICATIONS; OXIDATIVE STRESS; SKIN AUTOFLUORESCENCE; DIETARY GLYCOTOXINS; INVOLVEMENT; RECEPTOR; PROTEIN; AGES; ENDPRODUCTS;

D O I：

10.1007/s10439-024-03499-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Advanced glycation end products (AGEs) have garnered significant attention due to their association with chronic diseases and the aging process. The prevalence of geriatric diseases among young individuals has witnessed a notable surge in recent years, potentially attributed to the accelerated pace of modern life. The accumulation of AGEs is primarily attributed to their inherent difficulty in metabolism, which makes them promising biomarkers for chronic disease detection. This review aims to provide a comprehensive overview of the recent advancements and findings in AGE research. The discussion is divided into two main sections: endogenous AGEs (formed within the body) and exogenous AGEs (derived from external sources). Various aspects of AGEs are subsequently summarized, including their production pathways, pathogenic mechanisms, and detection methods. Moreover, this review delves into the future research prospects concerning AGEs. Overall, this comprehensive review underscores the importance of AGEs in the detection of chronic diseases and provides a thorough understanding of their significance. It emphasizes the necessity for further research endeavors to deepen our comprehension of AGEs and their implications for human health.

引用

页码：3145 / 3156

页数：12

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