Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows

被引:103
作者
Giustina, Andrea [1 ,2 ]
Bilezikian, John P. [3 ]
Adler, Robert A. [4 ,5 ]
Banfi, Giuseppe [6 ,7 ]
Bikle, Daniel D. [8 ,9 ,10 ]
Binkley, Neil C. [11 ]
Bollerslev, Jens [12 ]
Bouillon, Roger [13 ]
Brandi, Maria Luisa [14 ]
Casanueva, Felipe F. [15 ,16 ]
di Filippo, Luigi [1 ,2 ]
Donini, Lorenzo M. [17 ]
Ebeling, Peter R. [18 ]
Fuleihan, Ghada El-Hajj [19 ]
Fassio, Angelo [20 ]
Frara, Stefano [1 ,2 ]
Jones, Glenville [21 ]
Marcocci, Claudio [22 ]
Martineau, Adrian R. [23 ]
Minisola, Salvatore [24 ]
Napoli, Nicola [25 ]
Procopio, Massimo [26 ]
Rizzoli, Rene [27 ,28 ]
Schafer, Anne L. [8 ,9 ]
Sempos, Christopher T. [29 ]
Ulivieri, Fabio Massimo [1 ,2 ]
Virtanen, Jyrki K. [30 ]
机构
[1] San Raffaele Vita Salute Univ, Inst Endocrine & Metab Sci, I-20132 Milan, Italy
[2] IRCCS Hosp, I-20132 Milan, Italy
[3] Vagelos Coll Phys & Surg, Dept Med, PH 8E105G,630 W 168th St, New York, NY 10032 USA
[4] Richmond Vet Affairs Med Ctr, Richmond, VA 23284 USA
[5] Virginia Commonwealth Univ, Richmond, VA 23284 USA
[6] IRCCS Galeazzi St Ambrogio Hosp, I-20161 Milan, Italy
[7] San Raffaele Vita Salute Univ, I-20132 Milan, Italy
[8] Univ Calif San Francisco, Dept Med, San Francisco, CA 94121 USA
[9] San Francisco Vet Affairs Hlth Ctr, San Francisco, CA 94121 USA
[10] Univ Calif San Francisco, Dept Endocrinol, San Francisco, CA 94121 USA
[11] Univ Wisconsin Madison, Sch Med & Publ Hlth, Madison, WI 53726 USA
[12] Univ Oslo, Fac Med, N-0313 Oslo, Norway
[13] Katholieke Univ Leuven, Dept Chron Dis Metab & Ageing, Lab Clin & Expt Endocrinol, B-3000 Leuven, Belgium
[14] Italian Fdn Res Bone Dis FIRMO, I-50129 Florence, Italy
[15] Santiago de Compostela Univ, Complejo Hospitalario Univ, Dept Med, Inst Invest Sanitaria IDIS, Santiago De Compostela 15706, Spain
[16] Santiago de Compostela Univ, CIBER Fisiopatol Obes & Nutr CIBERobn, Santiago De Compostela 15706, Spain
[17] Sapienza Univ, Dept Expt Med, I-00161 Rome, Italy
[18] Monash Univ, Sch Clin Sci, Dept Med, Clayton 3168, Australia
[19] Amer Univ Beirut, Div Endocrino, WHO CC Metab Bone Disorders, Calcium Metab & Osteoporosis Program, Beirut 11072020, Lebanon
[20] Univ Verona, Rheumatol Unit, I-37129 Verona, Italy
[21] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada
[22] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy
[23] Queen Mary Univ London, Fac Med & Dent, London E1 4NS, England
[24] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy
[25] Campus Biomed Univ Rome, Unit Endocrinol & Diabet, I-00128 Rome, Italy
[26] Univ Turin, Molinette Hosp, Div Endocrinol Diabetol & Metab Dis, I-10126 Turin, Italy
[27] Geneva Univ Hosp, CH-1205 Geneva, Switzerland
[28] Fac Med, CH-1205 Geneva, Switzerland
[29] Vitamin D Standardizat Program VDSP, Havre De Grace, MD 21078 USA
[30] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, FI-70211 Kuopio, Finland
关键词
vitamin D; cholecalciferol; calcitriol; calcifediol; vitamin D assay; Vitamin D Standardization Program (VDSP); MENDELIAN RANDOMIZATION ANALYSIS; 25-HYDROXYVITAMIN D RESPONSE; D-HEALTH TRIAL; D DEFICIENCY; D METABOLITES; DOUBLE-BLIND; D-RECEPTOR; SECONDARY HYPERPARATHYROIDISM; GENE-EXPRESSION; FRACTURE RISK;
D O I
10.1210/endrev/bnae009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The 6th International Conference, "Controversies in Vitamin D," was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake and that can be detected with distinctive noncanonical vitamin D metabolites. Optimal 25-hydroxyvitamin D (25(OH)D) levels remain debated. Varying recommendations from different societies arise from evaluating different clinical or public health approaches. The lack of assay standardization also poses challenges in interpreting data from available studies, hindering rational data pooling and meta-analyses. Beyond the well-known skeletal features, interest in vitamin D's extraskeletal effects has led to clinical trials on cancer, cardiovascular risk, respiratory effects, autoimmune diseases, diabetes, and mortality. The initial negative results are likely due to enrollment of vitamin D-replete individuals. Subsequent post hoc analyses have suggested, nevertheless, potential benefits in reducing cancer incidence, autoimmune diseases, cardiovascular events, and diabetes. Oral administration of vitamin D is the preferred route. Parenteral administration is reserved for specific clinical situations. Cholecalciferol is favored due to safety and minimal monitoring requirements. Calcifediol may be used in certain conditions, while calcitriol should be limited to specific disorders in which the active metabolite is not readily produced in vivo. Further studies are needed to investigate vitamin D effects in relation to the different recommended 25(OH)D levels and the efficacy of the different supplementary formulations in achieving biochemical and clinical outcomes within the multifaced skeletal and extraskeletal potential effects of vitamin D. Graphical Abstract
引用
收藏
页码:625 / 654
页数:30
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