Prognostic significance of occult vertebral fracture in patients undergoing pancreatic resection for pancreatic cancer

被引：5

作者：

Ishizaki, Shunta ^{[1
]}

Furukawa, Kenei ^{[1
,2
]}

Haruki, Koichiro ^{[1
]}

Tsunematsu, Masashi ^{[1
]}

Shirai, Yoshihiro ^{[1
]}

Matsumoto, Michinori ^{[1
]}

Okui, Norimitsu ^{[1
]}

Onda, Shinji ^{[1
]}

Taniai, Tomohiko ^{[1
]}

Ikegami, Toru ^{[1
]}

机构：

[1] Jikei Univ, Dept Surg, Div Hepatobiliary & Pancreas Surg, Sch Med, 3-25-8 Nishi Shinbashi,Minato Ku, Tokyo 1058461, Japan

[2] Jikei Univ, Dept Surg, Sch Med, 3-25-8 Nishi Shinbashi,Minato Ku, Tokyo 1058461, Japan

来源：

PANCREATOLOGY | 2024年 / 24卷 / 02期

关键词：

Pancreatic cancer; Osteopenia; Occult vertebral fracture; BONE-MINERAL DENSITY; OSTEOPOROSIS; GEMCITABINE; MANAGEMENT; SARCOPENIA; OUTCOMES; RISK;

D O I：

10.1016/j.pan.2024.01.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: The prognostic impact of occult vertebral fracture (OVF) in patients with malignancies is a new cutting edge in cancer research. This study was performed to analyze the prognostic impact of OVF after surgery for pancreatic cancer. Methods: This study involved 200 patients who underwent surgical treatment of pancreatic ductal adenocarcinoma. OVF was diagnosed by quantitative measurement using preoperative sagittal computed tomography image reconstruction from the 11th thoracic vertebra to the 5th lumbar vertebra. Results: OVF was diagnosed in 65 (32.5 %) patients. The multivariate analyses showed that male sex (p = 0.01), osteopenia (p < 0.01), OVF (p < 0.01), a carbohydrate antigen 19-9 level of >= 400 U/mL (p < 0.01), advanced stage of cancer (p < 0.01), and non-adjuvant chemotherapy (p = 0.02) were independent risk factors for overall survival. An age of >= 74 years (p < 0.01) and obstructive jaundice (p = 0.03) were independent risk factors for OVF. Furthermore, the combination of OVF and osteopenia further worsened disease-free survival and overall survival compared with osteopenia or OVF alone (p < 0.01; respectively). Conclusion: Evaluation of preoperative OVF might be a useful prognostic indicator for patients with pancreatic ductal adenocarcinoma. (c) 2024 IAP and EPC. Published by Elsevier B.V. All rights reserved.

引用

页码：249 / 254

页数：6

共 31 条

[1] Impact of osteopenia on surgical and oncological outcomes in patients with pancreatic cancer [J].

Abe, Kyohei ;

Furukawa, Kenei ;

Okamoto, Tomoyoshi ;

Matsumoto, Michinori ;

Futagawa, Yasuro ;

Haruki, Koichiro ;

Shirai, Yoshihiro ;

Ikegami, Toru .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2021, 26 (10) :1929-1937

[2] Overview of osteoporosis: pathophysiology and determinants of bone strength [J].

Bono, CM ;

Einhorn, TA .

EUROPEAN SPINE JOURNAL, 2003, 12 (Suppl 2) :S90-S96

[3]

Brierley J., 2016, The TNM Classification of Malignant Tumours, V8th

[4] Sarcopenia in pancreatic cancer: Effect on patient outcomes [J].

Choi, Moon Hyung ;

Yoon, Seung Bae .

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2022, 14 (12) :2302-2312

[5] FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer [J].

Conroy, T. ;

Hammel, P. ;

Hebbar, M. ;

Ben Abdelghani, M. ;

Wei, A. C. ;

Raoul, J. -L. ;

Chone, L. ;

Francois, E. ;

Artru, P. ;

Biagi, J. J. ;

Lecomte, T. ;

Assenat, E. ;

Faroux, R. ;

Ychou, M. ;

Volet, J. ;

Sauvanet, A. ;

Breysacher, G. ;

Di Fiore, F. ;

Cripps, C. ;

Kavan, P. ;

Texereau, P. ;

Bouhier-Leporrier, K. ;

Khemissa-Akouz, F. ;

Legoux, J. -L. ;

Juzyna, B. ;

Gourgou, S. ;

O'Callaghan, C. J. ;

Jouffroy-Zeller, C. ;

Rat, P. ;

Malka, D. ;

Castan, F. ;

Bachet, J. -B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (25) :2395-2406

[6] Sarcopenia: European consensus on definition and diagnosis [J].

Cruz-Jentoft, Alfonso J. ;

Baeyens, Jean Pierre ;

Bauer, Juergen M. ;

Boirie, Yves ;

Cederholm, Tommy ;

Landi, Francesco ;

Martin, Finbarr C. ;

Michel, Jean-Pierre ;

Rolland, Yves ;

Schneider, Stephane M. ;

Topinkova, Eva ;

Vandewoude, Maurits ;

Zamboni, Mauro .

AGE AND AGEING, 2010, 39 (04) :412-423

[7] Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden [J].

de Castro, Luis F. ;

Burke, Andrea B. ;

Wang, Howard D. ;

Tsai, Jeffrey ;

Florenzano, Pablo ;

Pan, Kristen S. ;

Bhattacharyya, Nisan ;

Boyce, Alison M. ;

Gafni, Rachel I. ;

Molinolo, Alfredo A. ;

Robey, Pamela G. ;

Collins, Michael T. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 34 (02) :290-294

[8] Bone mass density, subsequent risk of colon cancer and survival in postmenopausal women [J].

Ganry, Olivier ;

Lapotre-Ledoux, B. ;

Fardellone, P. ;

Dubreuil, A. .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2008, 23 (07) :467-473

[9] Management of Osteoporosis and Spinal Fractures: Contemporary Guidelines and Evolving Paradigms [J].

Imamudeen, Nasvin ;

Basheer, Amjad ;

Iqbal, Anoop Mohamed ;

Manjila, Nihal ;

Haroon, Nisha Nigil ;

Manjila, Sunil .

CLINICAL MEDICINE & RESEARCH, 2022, 20 (02) :95-106

[10] A Prospective Randomized Controlled Study Comparing Outcomes of Standard Resection and Extended Resection, Including Dissection of the Nerve Plexus and Various Lymph Nodes, in Patients With Pancreatic Head Cancer [J].

Jang, Jin-Young ;

Kang, Mee Joo ;

Heo, Jin Seok ;

Choi, Seong Ho ;

Choi, Dong Wook ;

Park, Sang Jae ;

Han, Sung-Sik ;

Yoon, Dong Sup ;

Yu, Hee Chul ;

Kang, Koo Jeong ;

Kim, Sang Geol ;

Kim, Sun-Whe .

ANNALS OF SURGERY, 2014, 259 (04) :656-664

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