Determination of perfluorooctane sulfonic acid in cosmetics by high-perfor⁃ mance liquid chromatography-tandem mass spectrometry

被引：0

作者：

Wang, Xinran ^{[1
]}

Yin, Weicheng ^{[2
]}

Wang, Haiyan ^{[1
]}

Lu, Yong ^{[1
]}

机构：

[1] National Institutes for Food and Drug Control, NMPA Key Laboratory for Researching and Evaluation of Cosmetics, Beijing,100050, China

[2] Hunan Institute for Drug Control, Changsha,410000, China

来源：

Chinese Journal of Analysis Laboratory | 2023年 / 42卷 / 04期

关键词：

High performance liquid chromatography - Mass spectrometry - Methanol;

D O I：

10.13595/j.cnki.issn1000-0720.2022.030101

中图分类号：

学科分类号：

摘要：

A high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS）method was developed for the determination of perfluorooctane sulfonic acid （PFOS）in cosmetics. The cosmetic samples were extracted with methanol by ultrasonication，and PFOS was quantified by HPLC-MS/MS. The samples were detected in negative multiple reaction monitoring（MRM）mode using an Agilent Poroshell 120 EC-C18 （100 mm× 2.1 mm，2.7 µμm）column with a gradient elution using 0.1% formic acid aqueous solution（A）-methanol（B）as the mobile phase. The results showed that the linearity of PFOS was good in the range of 1-100 µμg/L with the correlation coefficient r2 larger than 0.9998；the limits of detection and limits of quantification were 0.015 and 0.050 mg/kg，respectively. The average recoveries were 98.7%-112.5%，and the relative standard deviations （RSDs）were less than 5%. The method is suitable for the determination of PFOS in cosmetics. © 2023, Youke Publishing Co.,Ltd. All rights reserved.

引用

页码：564 / 568