Aquaculture derived hybrid skin patches for wound healing

被引：0
作者：
Cao X. [1 ]
Sun L. [1 ]
Luo Z. [1 ]
Lin X. [1 ]
Zhao Y. [1 ,2 ]
机构：
[1] Department of Rheumatology and Immunology, School of Biological Science and Medical Engineering, Nanjing Drum Tower Hospital, Southeast University, Nanjing
[2] Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Zhejiang, Wenzhou
来源：
Engineered Regeneration | 2023年 / 4卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Bioactive; Biomaterial; Fish skin; Patch; Wound healing;
D O I：
10.1016/j.engreg.2022.11.002
中图分类号：
学科分类号：
摘要：
Natural biomaterials have been widely applied in wound treatment. Hotspots in this area are focused on reducing their immunogenicity and improving their therapeutic effect. In this work, we present a novel aquaculture derived hybrid skin patch based on acellular fish skin (AFS) and chitosan (CS) for wound healing. Such functional patch was simply constructed by infiltrating the vascular endothelial growth factor (VEGF)-loaded CS pregel into the porous scaffold of the AFS. As the natural molecules and structure of fish skin are well-retained during the synthesis processes, the final patch presented brilliant tensile property, water-absorption property, good biocompatibility and low immunogenicity. In addition, the integrated CS and VEGF endow the patch with antibacterial and angiogenesis capability respectively for promoting tissue growth and wound healing. Thus, in a full-thickness wound rat model, the hybrid patch has been demonstrated with dramatic therapeutic efficacy in inhibiting inflammatory, accelerating angiogenesis, collagen deposition, and tissue generation during the wound repair procedure. These features imply the practical value of this multifunctional aquaculture derived hybrid skin patch in clinical wound management. © 2022
引用
收藏
页码：28 / 35
页数：7
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