Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations

被引：32
作者：
Liu, Juan [1 ,2 ]
Song, Qingru [3 ]
Yin, Wenzhen [3 ]
Li, Chen [1 ,4 ]
An, Ni [3 ]
Le, Yinpeng [1 ,5 ]
Wang, Qi [1 ,6 ]
Feng, Yutian [1 ]
Hu, Yuelei [1 ,6 ]
Wang, Yunfang [1 ,2 ,3 ]
机构：
[1] Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Hepatopancreatobiliary Ctr, Sch Clin Med, Beijing 102218, Peoples R China
[2] Tsinghua Univ, Key Lab Digital Intelligence Hepatol, Minist Educ, Sch Clin Med, Beijing, Peoples R China
[3] Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Clin Translat Sci Ctr, Beijing, Peoples R China
[4] Beijing Univ Technol, Coll Chem & Life Sci, Beijing, Peoples R China
[5] Zhejiang Sci Tech Univ, Inst Smart Biomed Mat, Sch Mat Sci & Engn, Hangzhou, Peoples R China
[6] Jilin Univ, First Hosp Jilin Univ, Dept Hepatobiliary & Pancreat Surg, Changchun, Peoples R China
来源：
EXPLORATION | 2025年 / 5卷 / 01期
基金：
中国国家自然科学基金;
关键词：
3D scaffolds; decellularization; extracellular matrix; native microenvironment; tissue engineering; MESENCHYMAL STEM-CELLS; SUPERCRITICAL CARBON-DIOXIDE; REGENERATIVE MEDICINE; ORTHOTOPIC TRANSPLANTATION; CYTOCOMPATIBLE SCAFFOLD; BIOLOGIC SCAFFOLDS; DERMAL MATRIX; DIFFERENTIATION; ORGAN; PROLIFERATION;
D O I：
10.1002/EXP.20230078
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Decellularized extracellular matrix (dECM) offers a three-dimensional, non-immunogenic scaffold, enriched with bioactive components, making it a suitable candidate for tissue regeneration. Although dECM-based scaffolds have been successfully implemented in preclinical and clinical settings within tissue engineering and regenerative medicine, the mechanisms of tissue remodeling and functional restoration are not fully understood. This review critically assesses the state-of-the-art in dECM scaffolds, including decellularization techniques for various tissues, quality control and cross-linking. It highlights the functional properties of dECM components and their latest applications in multiorgan tissue engineering and biomedicine. Additionally, the review addresses current challenges and limitations of decellularized scaffolds and offers perspectives on future directions in the field.
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页数：29
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