Novel Fe3O4 Nanoparticles with Bioactive Glass-Naproxen Coating: Synthesis, Characterization, and In Vitro Evaluation of Bioactivity

被引：4

作者：

Valverde, Thalita Marcolan ^{[1
]}

Rebello dos Santos, Viviane Martins ^{[2
]}

Macario Viana, Pedro Igor ^{[1
]}

Jardim Costa, Guilherme Mattos ^{[1
]}

de Goes, Alfredo Miranda ^{[3
]}

Dutra Sousa, Lucas Resende ^{[4
]}

Xavier, Viviane Flores ^{[4
]}

de Abreu Vieira, Paula Melo ^{[5
]}

Silva, Daniel de Lima ^{[2
]}

Domingues, Rosana Zacarias ^{[6
]}

da Fonte Ferreira, Jose Maria ^{[7
]}

Andrade, Angela Leao ^{[2
,7
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Dept Morfol, Inst Ciencias Biol ICB, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Ouro Preto UFOP, Dept Quim, Inst Ciencias Exatas & Biol ICEB, BR-35400000 Ouro Preto, MG, Brazil

[3] Univ Fed Minas Gerais UFMG, Dept Patol Geral, Inst Ciencias Biol ICB, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Ouro Preto UFOP, Lab Fitotecnol, Escola Farm, Programa Posgrad Ciencias Farmaceut, BR-35400000 Ouro Preto, MG, Brazil

[5] Univ Fed Ouro Preto UFOP, Lab Morfopatol, Nucleo Pesquisas Ciencias Biol, BR-35400000 Ouro Preto, MG, Brazil

[6] Univ Fed Minas Gerais UFMG, Dept Quim, Inst Ciencias Exatas ICEx, BR-31270901 Belo Horizonte, MG, Brazil

[7] Univ Aveiro UA, Dept Engn Mat & Ceram, CICECO, P-3810193 Aveiro, Portugal

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 08期

关键词：

magnetic nanoparticles; silica; naproxen; biocompatibility; NITRIC-OXIDE; SYSTEM; THERAPY; GROWTH; NANOMATERIALS; HYPERTHERMIA; ASSOCIATION; MACROPHAGES; EXPRESSION; PHYSIOLOGY;

D O I：

10.3390/ijms25084270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune response to biomaterials, which is intimately related to their surface properties, can produce chronic inflammation and fibrosis, leading to implant failure. This study investigated the development of magnetic nanoparticles coated with silica and incorporating the anti-inflammatory drug naproxen, aimed at multifunctional biomedical applications. The synthesized nanoparticles were characterized using various techniques that confirmed the presence of magnetite and the formation of a silica-rich bioactive glass (BG) layer. In vitro studies demonstrated that the nanoparticles exhibited bioactive properties, forming an apatite surface layer when immersed in simulated body fluid, and biocompatibility with bone cells, with good viability and alkaline phosphatase activity. Naproxen, either free or encapsulated, reduced nitric oxide production, an inflammatory marker, while the BG coating alone did not show anti-inflammatory effects in this study. Overall, the magnetic nanoparticles coated with BG and naproxen showed promise for biomedical applications, especially anti-inflammatory activity in macrophages and in the bone field, due to their biocompatibility, bioactivity, and osteogenic potential.

引用

页数：26

共 94 条

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