Early Screening for the Parkinson Variant of Multiple System Atrophy: A 6-Item Score

被引：2

作者：

Fanciulli, Alessandra ^{[1
]}

Stankovic, Iva ^{[2
,3
]}

Avraham, Omer ^{[4
,5
]}

Lukic, Milica Jecmenica ^{[2
,3
]}

Ezra, Adi ^{[4
]}

Leys, Fabian ^{[1
]}

Goebel, Georg ^{[6
]}

Krismer, Florian ^{[1
]}

Petrovic, Igor ^{[2
,3
]}

Svetel, Marina ^{[2
,3
]}

Seppi, Klaus ^{[1
,7
]}

Kostic, Vladimir ^{[2
,3
]}

Giladi, Nir ^{[4
,5
,8
]}

Poewe, Werner ^{[1
]}

Wenning, Gregor K. ^{[1
]}

Gurevich, Tanya ^{[4
,5
,8
]}

机构：

[1] Med Univ Innsbruck, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria

[2] Univ Clin Ctr Serbia, Neurol Clin, Belgrade, Serbia

[3] Univ Belgrade, Fac Med, Belgrade, Serbia

[4] Neurol Inst, Tel Aviv Med Ctr, Movement Disorders Unit, Tel Aviv, Israel

[5] Tel Aviv Univ, Sch Med, Sagol Sch Neurosci, Tel Aviv, Israel

[6] Med Univ Innsbruck, Inst Med Stat & Informat, Innsbruck, Austria

[7] Prov Hosp Kufstein, Dept Neurol, Kufstein, Austria

[8] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel

来源：

MOVEMENT DISORDERS CLINICAL PRACTICE | 2024年 / 11卷 / 07期

基金：

奥地利科学基金会;

关键词：

multiple system atrophy; Parkinson's disease; orthostatic hypotension; bladder dysfunction; postural instability; ORTHOSTATIC HYPOTENSION; PROGRESSION; HOEHN;

D O I：

10.1002/mdc3.14048

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundA 4-item score based on >= 2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity. ObjectivesTo replicate and improve the 4-item MSA-P score. MethodsWe retrospectively studied 161 patients with early parkinsonism [ie, <= 2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after >= 24 months follow-up. ResultsThe 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range: 0-6), reaching >= 3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity. ConclusionsThe 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.

引用

页码：867 / 873

页数：7

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