Essential oil of Eugenia stictopetala Mart. ex DC. has antioxidant, antibacterial, and gastrointestinal protective effect

被引：0

作者：

de Veras, Bruno Oliveira ^{[1
,2
]}

Felix, Rianne Ferreira ^{[3
]}

Moura, Geovanna Maria de Medeiros ^{[4
]}

Navarro, Daniela Maria do Amaral Ferraz ^{[5
]}

Aguiar, Julio Cesar Ribeiro de Oliveira Farias de ^{[5
]}

Wanderley, Almir Goncalves ^{[6
]}

da Silva, Marcia Vanusa ^{[2
]}

Correia, Maria Tereza dos Santos ^{[2
]}

机构：

[1] Univ Fed Pernambuco, Postgrad Biotechnol RENORBIO, Recife, PE, Brazil

[2] Univ Fed Pernambuco, Dept Biochem, Lab Nat Prod, Recife, PE, Brazil

[3] Univ Fed Pernambuco, Postgrad Biol Sci, Recife, PE, Brazil

[4] Univ Fed Rio Grande do Norte, Dept Biochem, Lab Chem & Funct Bioact Prot, Natal, RN, Brazil

[5] Univ Fed Pernambuco, Ctr Exact & Nat Sci, Dept Chem, BR-50670420 Recife, PE, Brazil

[6] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, SP, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Antidiarrheal activity; gastroprotective; caryophyllene; ABTS; Eugenia stictopetala; Caja-Pitanga; CHEMICAL-COMPOSITION; DYSENTERICA DC; MYRTACEAE;

D O I：

10.1080/14786419.2024.2342556

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This work aimed to investigate the chemical composition, antioxidant capacity, antibacterial activity, and intestinal and gastric protective effects, in addition to the acute toxicity of the essential oil of E. stictopetala (EOEs). (E)-caryophyllene (18.01%), beta-pinene (8.84%), and (E)-nerolidol (8.24%), were the components found in higher content in the essential oil. The EOEs showed antioxidant capacity with IC50 values ranging from 220.28 to 283.67 mu g/mL, in addition to presenting antibacterial activity against Escherichia coli, Enterobacter aerogenes, Vibrio cholerae, Salmonella enterica, and Listeria monocytogenes. The essential oil showed a gastroprotective effect, with a reduction in the levels of TNF-alpha, IL-1 beta, and IL-6, having multiple pharmacological mechanisms of action. An antidiarrheal effect of EOEs was observed in the castor oil-induced diarrheal model, with reduced intestinal motility. Our findings demonstrate that essential oil can be beneficial in pharmaceutical and therapeutic applications for treating gastrointestinal diseases.

引用

页数：5

共 21 条

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