Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study

Objective: Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both agerelated conditions and cardiovascular disorders. This research was aimed at examining the link between MMA and abdominal aortic calcification (AAC). Methods: Data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) were analyzed. Serum MMA levels were determined through LC-MS/MS, and MMA levels 250 nmol/L or above were considered high. Dual-energy X-ray absorptiometry was used to assess the presence of AAC. Logistic regression analysis was performed after propensity score matching (PSM) to study the relationship between MMA and AAC. Results: A total of 2483 participants were involved in this study. To eliminate large differences between the AAC and non-AAC groups, 1:1 PSM was performed. Logistic regression analysis indicated that participants with high MMA levels had a significantly greater likelihood of experiencing AAC than those with low MMA levels (OR: 1.38, 95% CI: 1.01-1.90, P = 0.046). No statistically interaction effects between AAC and BMI or the estimated glomerular filtraConclusion: Our study indicated a significant association between high serum MMA levels and AAC incidence.