Advancements in the application of nanotechnology for the management of epileptic seizures

被引：1

作者：

Ping, Honglu ^{[1
]}

Ding, Ding ^{[1
]}

Zhu, Guoxing ^{[1
]}

Wang, Jianhong ^{[1
]}

Zhang, Jun ^{[2
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurol, 12 Wulumuqi Middle Rd, Shanghai 200040, Peoples R China

[2] Fudan Univ, Huashan Hosp, Natl Ctr Neurol Disorders, Dept Radiol,State Key Lab Med Neurobiol, Wulumuqi Middle Rd 12, Shanghai 200040, Peoples R China

来源：

ACTA EPILEPTOLOGICA | 2024年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Epilepsy; Nanomaterials; Stimulus response system; Blood-brain barrier; Drug delivery; ANTIEPILEPTIC DRUGS; OXIDATIVE STRESS; INTRACELLULAR PH; BRAIN; NANOPARTICLES; DELIVERY; MODULATION; GLYCOPROTEIN; TRANSPORTERS; RESISTANCE;

D O I：

10.1186/s42494-024-00171-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Epilepsy is a common yet complex neurological disorder. Historically, antiseizure medications (ASMs) have faced challenges in crossing the blood-brain barrier (BBB) and targeting the epileptogenic zone, creating a bottleneck in seizure management. Certain nanomaterials can facilitate drug penetration through the BBB and enable stimulus-responsive drug release, thereby enhancing targeted and efficient drug utilization while reducing adverse reactions in other brain tissues and peripherally. This article reviews the current researches on stimulus-responsive nanosystems applicable in antiepileptic therapy, as well as nanotechnology applications that improve the brain delivery of ASMs.

引用

页数：10

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