Targeting TRP channels for pain relief: A review of current evidence from bench to bedside

被引：8
作者：
Koivisto, Ari-Pekka [1 ]
Voets, Thomas [2 ,3 ]
Iadarola, Michael J. [4 ]
Szallasi, Arpad [5 ]
机构：
[1] Orion Pharm Corp, Pain Therapy Area, R&D, Turku, Finland
[2] Katholieke Univ Leuven, Lab Ion Channel Res, Ctr Brain & Dis Res, VIB, Leuven, Belgium
[3] Katholieke Univ Leuven, Dept Cellular & Mol Med, Leuven, Belgium
[4] NIH, Clin Ctr, Dept Perioperat Med, Bethesda, MD USA
[5] Semmelweis Univ, Dept Pathol & Expt Canc Res, Budapest, Hungary
来源：
CURRENT OPINION IN PHARMACOLOGY | 2024年 / 75卷
关键词：
lecular Medicine; Leuven; Belgium; RECEPTOR POTENTIAL CHANNELS; CAPSAICIN RECEPTOR; ION-CHANNEL; PERIPHERAL NEUROPATHY; VANILLOID RECEPTOR-1; CATION CHANNEL; DOUBLE-BLIND; EXPRESSION; OSTEOARTHRITIS; INFLAMMATION;
D O I：
10.1016/j.coph.2024.102447
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.
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页数：10
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