Metal-based porous hydrogels for highly conductive biomaterial scaffolds (vol 3, itad002, 2023)

被引：0

作者：

Tringides, Christina M.

Boulingre, Marjolaine

Mooney, David J.

机构：

[1] Program in Biophysics, Harvard University, Cambridge, 02138, MA

[2] Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, 02115, MA

[3] John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, 02138, MA

[4] Harvard–MIT Division in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02142, MA

[5] Department of Bioengineering, Imperial College London, London

来源：

OXFORD OPEN MATERIALS SCIENCE | 2023年 / 3卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

3D biology; biohybrid electronics; biomaterials; composites; conductive scaffolds; hydrogels; tissue engineering;

D O I：

10.1093/oxfmat/itad006

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Multielectrode arrays are fabricated from thin films of highly conductive and ductile metals, which cannot mimic the natural environment of biological tissues. These properties limit the conformability of the electrode to the underlying target tissue and present challenges in developing seamless interfaces. By introducing porous, hydrogel materials that are embedded with metal additives, highly conductive hydrogels can be formed. Tuning the hydrogel composition, % volume and aspect ratio of different additive(s), and the processing conditions of these composite materials can alter the mechanical and electrical properties. The resulting materials have a high surface area and can be used as biomaterial scaffolds to support the growth of macrophages for 5 days. Further optimization can enable the use of the materials for the electrodes in implantable arrays, or as living electrode platforms, to study and modulate various cellular cultures. These advancements would benefit both in vivo and in vitro applications of tissue engineering. © The Author(s) 2023. Published by Oxford University Press.

引用

页数：1