Unveiling the Role of Pregnancy-Associated Plasma Protein A (PAPP-A) in Pregnancy-Associated Breast Cancer: A Comprehensive Review

被引：0

作者：

Patel, Archan ^{[1
]}

Dewani, Deepika ^{[1
]}

Jaiswal, Arpita ^{[1
]}

Reddy, Lucky Srivani ^{[1
]}

Yadav, Pallavi ^{[1
]}

Sethi, Neha ^{[1
]}

机构：

[1] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Obstet & Gynecol, Wardha, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 03期

关键词：

therapeutic targeting; diagnostic implications; cancer progression; tissue remodeling; papp-a; pregnancy- associated breast cancer; EPIDEMIOLOGY; TARGET;

D O I：

10.7759/cureus.56269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pregnancy-associated breast cancer (PABC) presents unique challenges due to its occurrence during or shortly after pregnancy. Pregnancy-associated plasma protein A (PAPP-A) has emerged as a potential biomarker and regulator in PABC. This comprehensive review examines the role of PAPP-A in PABC, highlighting its involvement in tissue remodeling and cancer progression. Molecular mechanisms linking PAPP-A to breast cancer, including signaling pathways and interactions with other molecules, are explored. The review also discusses the diagnostic and therapeutic implications of PAPP-A dysregulation in PABC, emphasizing the need for further research to elucidate underlying mechanisms and develop targeted therapies. Collaborative efforts among researchers, clinicians, and industry stakeholders are essential for translating findings into clinically relevant interventions to improve outcomes for PABC patients.

引用

页数：7

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