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[61]
Zhao W, Association between migraine and cardiovascular disease mortality: a prospective population-based cohort study
Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study
被引：3
作者：
Duan, Xirui
[1
]
Du, Xiaolan
[1
]
Zheng, Guangrong
[1
]
Zhou, Xinyan
[1
]
Tan, Na
[1
]
Li, Guochen
[1
]
Liu, Bin
[1
]
Zhu, Mei
[3
]
Ke, Tengfei
[2
]
Liao, Chengde
[1
]
机构：
[1] Kunming Med Univ, Yanan Hosp Kunming City, Yanan Hosp, Yunnan Cardiovasc Hosp,Dept Radiol, Kunming, Peoples R China
[2] Kunming Med Univ, Yunnan Canc Hosp Ctr, Affiliated Hosp 3, Dept Radiol, Kunming, Peoples R China
[3] Third Peoples Hosp Yunnan Prov, Dept Gen Practice, Kunming, Peoples R China
关键词：
Migraine;
Cardiovascular disease;
GWAS;
Causal association;
Mendelian randomization;
GENE-RELATED PEPTIDE;
DOUBLE-BLIND;
RISK;
INSTRUMENTS;
CGRP;
ASSOCIATION;
ATOGEPANT;
HORMONES;
BIAS;
D O I：
10.1186/s10194-024-01836-w
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
BackgroundWhile growing evidence suggests a relationship between migraine and cardiovascular disease, the genetic evidence for a causal relationship between migraine and cardiovascular disease is still scarce. Investigating the causal association between migraine and cardiovascular disease is vital.MethodsWe carried out a bidirectional Mendelian randomization (MR) study including discovery samples and replication samples using publicly available genome-wide association study (GWAS) summary datasets and stringent screening instrumental variables. Four different MR techniques-Inverse variance weighted (IVW), MR -Egger, weighted median, and weighted mode-as well as various sensitivity analyses-Cochran's Q, IVW radial, leave-one-out (LOO), and MR-PRESSO-were utilized to investigate the causal relationship between cardiovascular disease and migraine.ResultsThe protective causal effects of genetically predicted migraine on coronary artery disease (OR, 0.881; 95% CI 0.790-0.982; p = 0.023) and ischemic stroke (OR, 0.912; 95% CI 0.854-0.974; p = 0.006) were detected in forward MR analysis but not in any other cardiovascular disease. Consistently, we also discovered protective causal effects of coronary atherosclerosis (OR, 0.865; 95% CI 0.797-0.940; p = 0.001) and myocardial infarction (OR, 0.798; 95% CI 0.668-0.952; p = 0.012) on migraine in reverse MR analysis.ConclusionWe found a potential protective effect of migraine on coronary artery disease and ischemic stroke and a potential protective effect of coronary atherosclerosis and myocardial infarction on migraine. We emphasised epidemiological and genetic differences and the need for long-term safety monitoring of migraine medications and future research to improve cardiovascular outcomes in migraine patients.
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页数：12
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