Protective Effect of Hop Ethyl Acetate Extract on Corticosterone-Induced PC12 and Improvement of Depression-like Behavior in Mice

被引：2

作者：

Ma, Ziwei ^{[1
,2
]}

Yu, Yuming ^{[1
,2
]}

Gao, Ming ^{[1
,2
]}

Chen, Peng ^{[1
,2
]}

Hong, Huixia ^{[1
,2
]}

Yu, Dingle ^{[3
]}

Liang, Zhenjiang ^{[3
]}

Bai, Yu ^{[4
]}

Ye, Qinlian ^{[5
]}

Wang, Yachao ^{[5
,6
]}

Huang, Guodong ^{[7
,8
]}

Tan, Hui ^{[4
]}

机构：

[1] Xinjiang Univ, State Key Lab Chem & Utilizat Carbon Based Energy, Urumqi 830017, Xinjiang, Peoples R China

[2] Xinjiang Univ, Coll Chem, Urumqi 830017, Xinjiang, Peoples R China

[3] Shenzhen Childrens Hosp, Ctr Child Care & Mental Hlth CCCMH, Shenzhen 518038, Peoples R China

[4] Shantou Univ, Shenzhen Pediat Inst, Med Coll Hlth, Ctr Child Care & Mental Hlth, Shenzhen 518035, Peoples R China

[5] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Inst Translat Med, Shenzhen 518038, Peoples R China

[6] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Neurosurg, Shenzhen 518035, Peoples R China

[7] Shenzhen Univ, Affiliated Hosp 1, Dept Neurosurg, Shenzhen Key Lab Neurosurg,Inst Translat Med, Shenzhen 518035, Peoples R China

[8] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Inst Translat Med, Shenzhen 518035, Peoples R China

来源：

ACS CHEMICAL NEUROSCIENCE | 2024年 / 15卷 / 09期

基金：

中国国家自然科学基金;

关键词：

HEA; PC12; anti-inflammatory effect; depression; stress; synapse; NOREPINEPHRINE; MITOCHONDRIAL; RECEPTORS; SEROTONIN; PATHWAYS; DISORDER; ANXIETY; STRESS;

D O I：

10.1021/acschemneuro.4c00081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Depression is a common mental disorder. In recent years, more and more attention has been paid to depression and its etiology and pathogenesis. This review aims to explore the neuroprotective and antidepressant effects of hop components. By establishing an in vitro cell damage model using PC12 cells induced by corticosterone (CORT) and an in vivo depression model through the intracranial injection of lipopolysaccharide (LPS) in mice, hop ethyl acetate extract (HEA) was used to study the protective effect and mechanism of HEA on neuronal cells in vitro and the antidepression effect and mechanism in vivo. The results showed that HEA increased the survival and decreased the rate of lactate dehydrogenase (LDH) release, apoptosis, and the ROS and NO content of CORT-induced PC12 cells. HEA alleviated depressive-like behavior, neuroinflammation, reduction of norepinephrine, and dendritic spines induced by intracerebroventricular injection of LPS in mice and increases the expression levels of BDNF, SNAP 25, and TrkB proteins without any significant side effects or toxicity. Hops demonstrated significant comprehensive utilization value, and this work provided an experimental basis for the role of hops in the treatment of depression and provided a basis for the development of HEA for antidepressant drugs or dietary therapy products.

引用

页码：1893 / 1903

页数：11