Comprehensive analysis of gene expression profiles of annulus fibrosus subtypes and hub genes in intervertebral disc degeneration

被引：0

作者：

Zhao, Xiaokun ^{[1
]}

Zhang, Jian ^{[2
]}

Liu, Jiahao ^{[3
]}

Yuan, Jinghong ^{[1
]}

Wu, Tianlong ^{[1
]}

Cheng, Xigao ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Orthoped, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Jiangxi Key Lab Intervertebral Disc Dis, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Univ, Inst Minimally Invas Orthoped, Nanchang 330006, Jiangxi, Peoples R China

来源：

AGING-US | 2024年 / 16卷 / 06期

基金：

中国国家自然科学基金;

关键词：

intervertebral disc degeneration; annulus fibrosus; molecular subtype; WGCNA; machine learning; BIOINFORMATICS; BIOMARKERS; MECHANISM; PATHWAYS; PAIN;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intervertebral disc degeneration (IVDD) has been considered a major cause of low back pain. Therefore, further molecular subtypes of IVDD and identification of potential critical genes are urgently needed. First, consensus clustering was used to classify patients with IVDD into two subtypes and key module genes for subtyping were identified using weighted gene co -expression network analysis (WGCNA). Then, key module genes for the disease were identified by WGCNA. Subsequently, SVM and GLM were used to identify hub genes. Based on the above genes, a nomogram was constructed to predict the subtypes of IVDD. Finally, we find that ROM1 is lowered in IVDD and is linked to various cancer prognoses. The present work offers innovative diagnostic and therapeutic biomarkers for molecular subtypes of IVDD.

引用

页码：5370 / 5386

页数：17

共 40 条

[1]

Abdi Salahadin, 2007, Pain Physician, V10, P185

[2] Contribution of bioinformatics prediction in microRNA-based cancer therapeutics [J].

Banwait, Jasjit K. ;

Bastola, Dhundy R. .

ADVANCED DRUG DELIVERY REVIEWS, 2015, 81 :94-103

[3] Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations [J].

Brinjikji, W. ;

Luetmer, P. H. ;

Comstock, B. ;

Bresnahan, B. W. ;

Chen, L. E. ;

Deyo, R. A. ;

Halabi, S. ;

Turner, J. A. ;

Avins, A. L. ;

James, K. ;

Wald, J. T. ;

Kallmes, D. F. ;

Jarvik, J. G. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2015, 36 (04) :811-816

[4] Bioinformatics analyses of retinoblastoma reveal the retinoblastoma progression subtypes [J].

Cao, Manjing ;

Wang, Sha ;

Zou, Jing ;

Wang, Wanpeng .

PEERJ, 2020, 8

[5] Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy [J].

Chen, Jiaxing ;

Yang, Xinyu ;

Feng, Yi ;

Li, Qiaochu ;

Ma, Jingjin ;

Wang, Linbang ;

Quan, Zhengxue .

CELLS, 2022, 11 (21)

[6] Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats [J].

Chen, Qi ;

Yang, Qu ;

Pan, Chongzhi ;

Ding, Rui ;

Wu, Tianlong ;

Cao, Jian ;

Wu, Hui ;

Zhao, Xiaokun ;

Li, Bin ;

Cheng, Xigao .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 11

[7] Three hematologic/immune system-specific expressed genes are considered as the potential biomarkers for the diagnosis of early rheumatoid arthritis through bioinformatics analysis [J].

Cheng, Qi ;

Chen, Xin ;

Wu, Huaxiang ;

Du, Yan .

JOURNAL OF TRANSLATIONAL MEDICINE, 2021, 19 (01)

[8] Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals [J].

Cheung, Kenneth M. C. ;

Karppinen, Jaro ;

Chan, Danny ;

Ho, Daniel W. H. ;

Song, You-Qiang ;

Sham, Pak ;

Cheah, Kathryn S. E. ;

Leong, John C. Y. ;

Luk, Keith D. K. .

SPINE, 2009, 34 (09) :934-940

[9] Potential of Magnetic Resonance Imaging Findings to Refine Case Definition for Mechanical Low Back Pain in Epidemiological Studies A Systematic Review [J].

Endean, Alison ;

Palmer, Keith T. ;

Coggon, David .

SPINE, 2011, 36 (02) :160-169

[10] The Role of IL-6 and TMEM100 in Lumbar Discogenic Pain and the Mechanism of the Glycine-Serine-Threonine Metabolic Axis : A Metabolomic and Molecular Biology Study [J].

Guo, Zhaoyang ;

Ma, Yuanye ;

Wang, Yaqing ;

Xiang, Hongfei ;

Yang, Shang -You ;

Guo, Zhu ;

Wang, Ronghuan ;

Chen, Wujun ;

Xing, Dongming ;

Chen, Bohua ;

Tao, Hao ;

Wu, Xiaolin .

JOURNAL OF PAIN RESEARCH, 2023, 16 :437-461

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