Mortality and neurodevelopmental outcomes at 2 years' corrected age of very preterm infants with necrotising enterocolitis or spontaneous intestinal perforation: The EPIPAGE-2 cohort study

被引：5

作者：

Butler, Victoria ^{[1
]}

Treluyer, Ludovic ^{[1
,2
]}

Patkai, Juliana ^{[1
]}

Biset, Aline ^{[3
]}

Jarreau, Pierre-Henri ^{[1
,2
,4
]}

Ancel, Pierre-Yves ^{[2
,4
,5
,6
]}

Roze, Jean-Christophe ^{[6
,7
,8
]}

Marchand-Martin, Laetitia ^{[2
,6
]}

Durox, Melanie ^{[2
,6
]}

Lapillonne, Alexandre ^{[6
,9
,10
]}

Picaud, Jean-Charles ^{[6
,11
,12
]}

Mitanchez, Delphine ^{[6
,13
]}

Tscherning, Charlotte ^{[6
,14
,15
]}

Biran, Valerie ^{[6
,16
,17
]}

Cambonie, Gilles ^{[6
,18
,19
]}

Lopez, Emmanuel ^{[6
]}

Hascoet, Jean-Michel ^{[6
,20
,21
]}

Desfrere, Luc ^{[6
,22
]}

Chollat, Clement ^{[3
,23
]}

Zana-Taieb, Elodie ^{[1
,24
]}

Torchin, Heloise ^{[1
,2
]}

机构：

[1] Paris Cite Univ, Assistance Publ Hop Paris, Cochin Hosp, Neonatal Intens Care Unit, 53 Ave Observ, F-75014 Paris, France

[2] Paris Cite Univ, CRESS, Obstet Perinatal & Pediat Epidemiol Res Team EPOPe, INSERM,INRAE, F-75006 Paris, France

[3] Sorbonne Univ, Trousseau Hosp, Assistance Publ Hop Paris, Dept Neonatal Pediat, Paris, France

[4] FHU Prema, Paris, France

[5] Assistance Publ Hop Paris, Clin Invest Ctr P1419, Paris, France

[6] Nutr EPIPAGE 2 Study Grp, Paris, France

[7] CHU Nantes, Dept Neonatol, Nantes, France

[8] INSERM, UMR PhAN 1280 INRAE, CIC004, Nantes, France

[9] Hosp Necker Enfants Malad, Assistance Publ Hop Paris, Neonatal Intens Care Unit, Paris, France

[10] Paris Cite Univ, URP 7328, Paris, France

[11] Hosp Civils Lyon, Dept Neonatol, Croix Rousse Hosp, F-69677 Lyon, France

[12] Univ Claude Bernard Lyon 1, CarMen, INSERM, INRA, F-69310 Lyon, France

[13] Francois Rabelais Univ, Bretonneau Hosp, Dept Neonatol, F-37000 Tours, France

[14] Oslo Univ Hosp, Div Neonatol, N-0372 Oslo, Norway

[15] Univ Toulouse, CNRS, INSERM, Infin,UPS, Toulouse, France

[16] Hop Robert Debre, Assistance Publ Hop Paris, Neonatal Intens Care Unit, Paris, France

[17] Paris Cite Univ, INSERM, U1141, Paris, France

[18] Montpellier Univ, CHU Montpellier, Dept Neonatol, Montpellier, France

[19] Univ Montpellier, INSERM, UMR 1058, Montpellier, France

[20] Maternite Reg Univ Adolphe Pinard Nancy Univ, Dept Neonatol, Nancy, France

[21] Univ Lorraine, DevAH, Vandoeuvre Les Nancy, France

[22] Louis Mourier Hosp, Assistance Publ Hop Paris, Neonatal Intens Care Unit, Colombes, France

[23] Paris Cite Univ, NeuroDiderot, INSERM, Paris, France

[24] INSERM, U955, IMRB, Creteil, France

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2024年 / 183卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Necrotizing enterocolitis; Spontaneous intestinal perforation; Prematurity; Digestive surgery; Neurodevelopment; Mortality; BIRTH-WEIGHT INFANTS; INDOMETHACIN;

D O I：

10.1007/s00431-024-05675-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Purpose: The primary objective was to evaluate the impact of necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP) on mortality and neurodevelopmental outcomes at 2 years' corrected age (CA) in infants born before 32 weeks' gestation (WG). Methods: We studied neurodevelopment at 2 years' CA of infants with NEC or SIP who were born before 32 WG from the EPIPAGE-2 cohort study. The primary outcome was death or the presence of moderate-to-severe motor or sensory disability defined by moderate-to-severe cerebral palsy or hearing or visual disability. The secondary outcome was developmental delay defined by a score < 2 SDs below the mean for any of the five domains of the Ages and Stages Questionnaire. Results: At 2 years' CA, 46% of infants with SIP, 34% of infants with NEC, and 14% of control infants died or had a moderate-to-severe sensorimotor disability (p < 0.01). This difference was mainly due to an increase in in-hospital mortality in the infants with SIP or NEC. Developmental delay at 2 years' CA was more frequent for infants with SIP than controls (70.8% vs 44.0%, p = 0.02) but was similar for infants with NEC and controls (49.3% vs 44.0%, p = 0.5). On multivariate analysis, the likelihood of developmental delay was associated with SIP (adjusted odds ratio = 3.0, 95% CI 1.0-9.1) but not NEC as compared with controls. Conclusion: NEC and SIP significantly increased the risk of death or sensorimotor disability at 2 years' CA. SIP was also associated with risk of developmental delay at 2 years' CA.

引用

页码：4019 / 4028

页数：10

共 29 条

[21] Impact of sevoflurane anesthesia on cerebral blood flow in children younger than 2years [J].