Relevance of PNPLA3, TM6SF2, HSD17B13, and GCKR Variants to MASLD Severity in an Egyptian Population

被引:1
作者
Elmansoury, Nehal [1 ]
Megahed, Ahmed A. [2 ]
Kamal, Ahmed [3 ]
El-Nikhely, Nefertiti [4 ]
Labane, Marina [2 ]
Abdelmageed, Manal [5 ]
Daly, Ann K. [6 ]
Wahid, Ahmed [1 ]
机构
[1] Alexandria Univ, Fac Pharm, Dept Pharmaceut Biochem, Alexandria 21521, Egypt
[2] Alexandria Univ, Fac Pharm, Alexandria 21521, Egypt
[3] Alexandria Univ, Fac Med, Dept Internal Med & Hepatol, Alexandria 21131, Egypt
[4] Alexandria Univ, Inst Grad Studies & Res, Alexandria 21526, Egypt
[5] Alexandria Univ, Med Res Inst, Dept Expt & Clin Internal Med, Alexandria 21561, Egypt
[6] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Med Sch, Framlington Pl, Newcastle Upon Tyne NE2 4HH, England
关键词
non-alcoholic fatty liver disease; PNPLA3 rs738409 C>G; TM6SF2 rs58542926 C>T; GCKR rs1260326 T>C; FATTY LIVER-DISEASE; HISTOLOGICAL SEVERITY; GENE VARIANT; SUSCEPTIBILITY; METAANALYSIS; ASSOCIATION; RS58542926; EXPRESSION; NAFLD;
D O I
10.3390/genes15040455
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a frequent clinical condition globally. Single nucleotide polymorphisms (SNPs) associated with NAFLD have been proposed in the literature and based on bioinformatic screening. The association between NAFLD and genetic variants in Egyptians is still unclear. Hence, we sought to investigate the association of some genetic variants with NAFLD in Egyptians. Egyptians have been categorized into either the MASLD group (n = 205) or the healthy control group (n = 187). The severity of hepatic steatosis and liver fibrosis was assessed by a Fibroscan device. TaqMan-based genotyping assays were employed to explore the association of selected SNPs with MASLD. PNPLA3 rs738409 C>G variant is associated with the presence of MASLD with liver fibrosis, the severity of both hepatic steatosis and liver fibrosis, increased systolic and diastolic blood pressure and increased alanine aminotransferase (all p < 0.05), while the TM6SF2 rs58542926 C>T, HSD17B13 rs9992651 G>A, and GCKR rs1260326 T>C variants were not (all p > 0.05). The TM6SF2 rs58542926 T allele is associated with increased fasting blood glucose and a decreased waist circumference. The GCKR rs1260326 C allele is associated with decreased aspartate transaminase and diastolic blood pressure (all p < 0.05). Only after adjusting for the risk factors (age, sex, BMI, WC, HDL, TG, diabetes mellitus, and hypertension) F2 liver fibrosis score is negatively correlated with the HSD17B13 rs9992651 GA genotype. This study offers evidence for the association of the PNPLA3 rs738409 C>G variant with MASLD among Egyptians and for the association of the PNPLA3 rs738409 G allele, the TM6SF2 rs58542926 T allele, and the GCKR rs1260326 C allele with some parameters of cardiometabolic criteria.
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页数:18
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