m6A Methylation in Regulation of Antiviral Innate Immunity

被引：5

作者：

Karandashov, Ivan ^{[1
]}

Kachanov, Artyom ^{[1
]}

Dukich, Maria ^{[1
,2
]}

Ponomareva, Natalia ^{[1
,3
,4
]}

Brezgin, Sergey ^{[1
,3
]}

Lukashev, Alexander ^{[1
]}

Pokrovsky, Vadim S. ^{[5
,6
,7
]}

Chulanov, Vladimir ^{[8
]}

Kostyusheva, Anastasiya ^{[1
]}

Kostyushev, Dmitry ^{[1
,3
,9
]}

机构：

[1] First Moscow State Med Univ, Sechenov Univ, Martsinovsky Inst Med Parasitol Trop & Vector Born, Lab Genet Technol, Moscow 119048, Russia

[2] Lomonosov Moscow State Univ, Fac Virol, Moscow 119234, Russia

[3] Sirius Univ Sci & Technol, Div Biotechnol, Soci 354340, Russia

[4] Sechenov First Moscow State Med Univ, Dept Pharmaceut & Toxicol Chem, Moscow 119048, Russia

[5] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[6] Blokhin Natl Med Res Ctr Oncol, Moscow 115522, Russia

[7] RUDN Univ, Fac Biochem, Moscow 117198, Russia

[8] First Moscow State Med Univ, Sechenov Univ, Dept Infect Dis, Moscow 119048, Russia

[9] Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow 119234, Russia

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 04期

关键词：

TLR; RLR; herpesviruses; hepatitis viruses; coronaviruses; retroviruses; flaviviruses; adenoviruses; PATTERN-RECOGNITION RECEPTORS; TOLL-LIKE RECEPTORS; NF-KAPPA-B; MESSENGER-RNA; RIG-I; NUCLEAR-RNA; VIRAL-RNA; N-6-METHYLADENOSINE MODIFICATION; STRUCTURAL BASIS; GENE-EXPRESSION;

D O I：

10.3390/v16040601

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The epitranscriptomic modification m6A is a prevalent RNA modification that plays a crucial role in the regulation of various aspects of RNA metabolism. It has been found to be involved in a wide range of physiological processes and disease states. Of particular interest is the role of m6A machinery and modifications in viral infections, serving as an evolutionary marker for distinguishing between self and non-self entities. In this review article, we present a comprehensive overview of the epitranscriptomic modification m6A and its implications for the interplay between viruses and their host, focusing on immune responses and viral replication. We outline future research directions that highlight the role of m6A in viral nucleic acid recognition, initiation of antiviral immune responses, and modulation of antiviral signaling pathways. Additionally, we discuss the potential of m6A as a prognostic biomarker and a target for therapeutic interventions in viral infections.

引用

页数：28

共 156 条

[1] cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING [J].