Glioblastoma is the most prevalent primary brain tumor. Because glioblastomas are very vascular, they mayworsen the disease's neurologic symptoms by causing vasogenic brain edema and mass effects with a widerange of other symptoms. In this case report, a 42-year-old male complaining of severe headache,generalized weakness, and forgetfulness was brought to a territory care hospital, where a detailedneurological examination and investigations with magnetic resonance imaging (MRI) revealed a grade IV(high-grade) glioma at the right frontotemporal and capsuloganglionic regions of the brain, and wassuggested for surgery. Postoperatively, the patient was referred for chemotherapy, but due to severeweakness, fatigue, and motor deficits, he was referred for physiotherapy. Follow-up was conducted tomonitor the patient's progression using various outcome measures. These measures included the FunctionalIndependence Measure (FIM), the Intensive Care Unit (ICU) Mobility Scale, the Glasgow Coma Scale (GCS),the modified Rankin Scale (mRS), and the Karnofsky Performance Status (KPS) Scale. Significantimprovement was observed in the patient's symptoms, as tracked by these outcome measures. Therefore, itis important that a tailored rehabilitation protocol of six weeks was planned, focusing on palliative care andsome symptoms of weakness, reduced strength, tone, and breathlessness to prevent secondarycomplications like deep vein thrombosis, irritability, anxiety, forgetfulness, decreased balance, andcoordination in sitting. Since the prognosis of grade IV glioblastoma is poor, the goal-orientedrehabilitation program will help improve the palliative status and the overall quality of life of the patient