An Exploratory Assessment of Pre-Treatment Inflammatory Profiles in Gastric Cancer Patients

被引:2
作者
Feier, Catalin Vladut Ionut [1 ,2 ]
Muntean, Calin [3 ]
Faur, Alaviana Monique [4 ]
Vonica, Razvan Constantin [5 ]
Blidari, Andiana Roxana [6 ]
Murariu, Marius-Sorin [1 ,2 ]
Olariu, Sorin [1 ,2 ]
机构
[1] Victor Babes Univ Med & Pharm, Dept X Surg, Discipline Surg 1, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[2] Pius Brinzeu Clin Emergency Hosp, Surg Clin 1, Timisoara 300723, Romania
[3] Victor Babes Univ Med & Pharm, Dept 3 Funct Sci, Med Informat & Biostat, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[4] Victor Babes Univ Med & Pharm, Fac Med, Timisoara 300041, Romania
[5] Lucian Blaga Univ Sibiu, Fac Med, Preclin Dept, Discipline Physiol, Sibiu 550169, Romania
[6] Victor Babes Univ Med & Pharm, Dept IX Surg, Oncol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
关键词
gastric cancer; Systemic Immune-Inflammation Index; inflammation status; prognosis; postoperative complications; INDEX; SURVIVAL; SYMPTOMS; STOMACH; RATIOS;
D O I
10.3390/diseases12040078
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Gastric cancer ranks as the fifth most common cancer, and the assessment of inflammatory biomarkers in these patients holds significant promise in predicting prognosis. Therefore, data from patients undergoing surgical intervention for gastric cancer over a 7-year period were analyzed. This study was retrospective and involved a preoperative investigation of six inflammatory parameters derived from complete blood counts. Statistical analysis revealed a significant increase in the leucocyte-to-monocyte ratio (LMR) (p = 0.048), along with a significant decrease in the number of lymphocytes and monocytes compared to patients with successful discharge. Taking into consideration patients undergoing emergency surgery, a significant increase in the LMR (p = 0.009), neutrophil-to-lymphocyte ratio (NLR) (p = 0.004), Aggregate Index of Systemic Inflammation (AISI) (p = 0.01), and Systemic Immune-Inflammation Index (SII) (p = 0.028) was observed. Regarding relapse, these patients exhibited significant increases in AISI (p = 0.032) and SII (p = 0.047). Inflammatory biomarkers represent a valuable tool in evaluating and predicting the prognosis of patients with gastric cancer.
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页数:11
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