Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy

被引:3
作者
Zhang, Qingfei [1 ,2 ]
Kuang, Gaizhen [1 ,2 ]
Wang, Li [2 ]
Fan, Lu [2 ]
Zhou, Yechao [1 ]
Shang, Luoran [4 ,5 ]
Zhao, Yuanjin [1 ,3 ]
Sun, Weijian [1 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Wenzhou 325035, Peoples R China
[2] Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325001, Peoples R China
[3] Southeast Univ, Nanjing Drum Tower Hosp, Sch Biol Sci & Med Engn, Dept Rheumatol & Immunol, Nanjing 210096, Peoples R China
[4] Fudan Univ, Shanghai Xuhui Cent Hosp, Zhongshan Xuhui Hosp, Shanghai 200032, Peoples R China
[5] Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
Microfluidics; Compartmental microparticle; Biorthogonal chemistry; Chemotherapy; Photothermal therapy;
D O I
10.1186/s12951-024-02778-w
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Microcarrier is a promising drug delivery system demonstrating significant value in treating cancers. One of the main goals is to devise microcarriers with ingenious structures and functions to achieve better therapeutic efficacy in tumors. Here, inspired by the nucleus-cytoplasm structure of cells and the material exchange reaction between them, we develop a type of biorthogonal compartmental microparticles (BCMs) from microfluidics that can separately load and sequentially release cyclooctene-modified doxorubicin prodrug (TCO-DOX) and tetrazine-modified indocyanine green (Tz-ICG) for tumor therapy. The Tz-ICG works not only as an activator for TCO-DOX but also as a photothermal agent, allowing for the combination of bioorthogonal chemotherapy and photothermal therapy (PTT). Besides, the modification of DOX with cyclooctene significantly decreases the systemic toxicity of DOX. As a result, the developed BCMs demonstrate efficient in vitro tumor cell eradication and exhibit notable tumor growth inhibition with favorable safety. These findings illustrate that the formulated BCMs establish a platform for bioorthogonal prodrug activation and localized delivery, holding significant potential for cancer therapy and related applications.
引用
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页数:12
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