Neuroinflammation of Microglial Regulation in Alzheimer's Disease: Therapeutic Approaches

被引：17

作者：

Chen, Haiyun ^{[1
]}

Zeng, Yuhan ^{[2
,3
,4
,5
]}

Wang, Dan ^{[2
,3
,4
,5
]}

Li, Yichen ^{[6
]}

Xing, Jieyu ^{[1
]}

Zeng, Yuejia ^{[1
]}

Liu, Zheng ^{[7
]}

Zhou, Xinhua ^{[8
]}

Fan, Hui ^{[2
,3
,4
,5
]}

机构：

[1] Guangdong Pharmaceut Univ, Coll Pharm, Sch Integrat Pharm, Clin Pharm, Guangzhou 510006, Peoples R China

[2] Guangdong Metab Dis Res Ctr Integrated Chinese & W, Guangzhou 510006, Peoples R China

[3] Guangdong TCM Key Lab Metab Dis, Guangzhou 510006, Peoples R China

[4] Minist Educ China, Key Lab Glucolipid Metab Disorder, Guangzhou 510006, Peoples R China

[5] State Adm Tradit Chinese Med, Key Unit Modulating Liver Treat Hyperlipemia SATCM, Guangzhou 510006, Peoples R China

[6] Guangdong Med Univ, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China

[7] Foshan Univ, Sch Med, Foshan 528000, Peoples R China

[8] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou 510000, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 07期

关键词：

Alzheimer's disease; neuroinflammation; microglial activation; anti-inflammatory agents; microglial energy metabolic disorder; microglial regulation; MOUSE MODEL; AMYLOID-BETA; ANTIINFLAMMATORY AGENTS; TNF-ALPHA; ACTIVATION; BRAIN; TAU; INFLAMMATION; MACROPHAGES; INHIBITION;

D O I：

10.3390/molecules29071478

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is a complex degenerative disease of the central nervous system that is clinically characterized by a progressive decline in memory and cognitive function. The pathogenesis of AD is intricate and not yet fully understood. Neuroinflammation, particularly microglial activation-mediated neuroinflammation, is believed to play a crucial role in increasing the risk, triggering the onset, and hastening the progression of AD. Modulating microglial activation and regulating microglial energy metabolic disorder are seen as promising strategies to intervene in AD. The application of anti-inflammatory drugs and the targeting of microglia for the prevention and treatment of AD has emerged as a new area of research interest. This article provides a comprehensive review of the role of neuroinflammation of microglial regulation in the development of AD, exploring the connection between microglial energy metabolic disorder, neuroinflammation, and AD development. Additionally, the advancements in anti-inflammatory and microglia-regulating therapies for AD are discussed.

引用

页数：24

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