Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

被引：3
作者：
Jafarinia, Hamidreza [1 ]
Khalilimeybodi, Ali [2 ]
Barrasa-Fano, Jorge [3 ]
Fraley, Stephanie I. [4 ]
Rangamani, Padmini [2 ]
Carlier, Aurelie [1 ]
机构：
[1] Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Cell Biol Inspired Tissue Engn, Maastricht, Netherlands
[2] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA
[3] Katholieke Univ Leuven, Dept Mech Engn, Biomech Sect, Leuven, Belgium
[4] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
来源：
NPJ SYSTEMS BIOLOGY AND APPLICATIONS | 2024年 / 10卷 / 01期
关键词：
FOCAL ADHESION KINASE; HIPPO PATHWAY; FORCE TRANSMISSION; LIGAND-BINDING; E-CADHERIN; YAP; TRACTION; ACTIVATION; LOCALIZATION; COMPLEX;
D O I：
10.1038/s41540-024-00414-9
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.
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页数：14
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