The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities

被引：4

作者：

Zhang, Tianle ^{[1
]}

Pang, Chenxu ^{[1
]}

Xu, Mengxin ^{[1
]}

Zhao, Qianqian ^{[2
]}

Hu, Zhijie ^{[1
]}

Jiang, Xijuan ^{[1
]}

Guo, Maojuan ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Sch Med Technol, Tianjin, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2024年 / 85卷 / 02期

关键词：

Atherosclerosis; Innate immunity; Adaptive immunity; Complement system; Pattern recognition receptors; Contents; LOW-DENSITY-LIPOPROTEIN; TOLL-LIKE RECEPTOR-3; NATURAL-KILLER-CELLS; SMOOTH-MUSCLE-CELLS; PLASMINOGEN-ACTIVATOR INHIBITOR-1; TERMINAL COMPLEMENT COMPLEX; ABDOMINAL AORTIC-ANEURYSM; B-CONTAINING LIPOPROTEINS; CD8(+) T-CELLS; NF-KAPPA-B;

D O I：

10.1016/j.humimm.2024.110765

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Numerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis. Additionally, the finding of numerous complement components in atherosclerotic plaques suggests yet again how heavily the immune system controls atherosclerosis. Therefore, it is essential to have a thorough grasp of how the immune system contributes to atherosclerosis. The specific molecular mechanisms involved in the activation of immune cells and immune molecules in atherosclerosis, the controversy surrounding some immune cells in atherosclerosis, and the limitations of extrapolating from relevant animal models to humans were all carefully reviewed in this review from the three perspectives of innate immunity, adaptive immunity, and complement system. This could provide fresh possibilities for atherosclerosis research and treatment in the future.

引用

页数：26

共 424 条

[1] Response to Letter Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet" [J].

Abderrazak, Amna ;

Couchie, Dominique ;

Mahmood, Dler Faieeq Darweesh ;

Elhage, Rima ;

Vindis, Cecile ;

Laffargue, Muriel ;

Mateo, Veronique ;

Buechele, Berthold ;

Ayala, Monica Rubio ;

El Gaafary, Menna ;

Syrovets, Tatiana ;

Slimane, Mohamed-Naceur ;

Friguet, Bertrand ;

Fulop, Tamas ;

Simmet, Thomas ;

El Hadri, Khadija ;

Rouis, Mustapha .

CIRCULATION, 2015, 132 (21) :e250-e251

[2] Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients [J].

Afrasyab, Altaf ;

Qu, Peng ;

Zhao, Yang ;

Peng, Kuang ;

Wang, Hongyan ;

Lou, Dayuan ;

Niu, Nan ;

Yuan, Dajun .

HEART AND VESSELS, 2016, 31 (08) :1218-1229

[3] An overview of mast cell pattern recognition receptors [J].

Agier, Justyna ;

Pastwinska, Joanna ;

Brzezinska-Blaszczyk, Ewa .

INFLAMMATION RESEARCH, 2018, 67 (09) :737-746

[4] B cell depletion reduces the development of atherosclerosis in mice [J].

Ait-Oufella, Hafid ;

Herbin, Olivier ;

Bouaziz, Jean-David ;

Binder, Christoph J. ;

Uyttenhove, Catherine ;

Laurans, Ludivine ;

Taleb, Soraya ;

Van Vre, Emily ;

Esposito, Bruno ;

Vilar, Jose ;

Sirvent, Jerome ;

Van Snick, Jacques ;

Tedgui, Alain ;

Tedder, Thomas F. ;

Mallat, Ziad .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (08) :1579-1587

[5] Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5 [J].

Alard, Jean-Eric ;

Ortega-Gomez, Almudena ;

Wichapong, Kanin ;

Bongiovanni, Dario ;

Horckmans, Michael ;

Megens, Remco T. A. ;

Leoni, Giovanna ;

Ferraro, Bartolo ;

Rossaint, Jan ;

Paulin, Nicole ;

Ng, Judy ;

Ippel, Hans ;

Suylen, Dennis ;

Hinkel, Rabea ;

Blanchet, Xavier ;

Gaillard, Fanny ;

D'Amico, Michele ;

von Hundelshausen, Phillipp ;

Zarbock, Alexander ;

Scheiermann, Christoph ;

Hackeng, Tilman M. ;

Steffens, Sabine ;

Kupatt, Christian ;

Nicolaes, Gerry A. F. ;

Weber, Christian ;

Soehnlein, Oliver .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (317)

[6] The role of the vascular dendritic cell network in atherosclerosis [J].

Alberts-Grill, Noah ;

Denning, Timothy L. ;

Rezvan, Amir ;

Jo, Hanjoong .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2013, 305 (01) :C1-C21

[7] Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice [J].

Alexopoulou, L ;

Thomas, V ;

Schnare, M ;

Lobet, Y ;

Anguita, J ;

Schoen, RT ;

Medzhitov, R ;

Fikrig, E ;

Flavell, RA .

NATURE MEDICINE, 2002, 8 (08) :878-884

[8] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[9] CYTOKINES AND GROWTH-FACTORS POSITIVELY AND NEGATIVELY REGULATE INTERSTITIAL COLLAGEN GENE-EXPRESSION IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS [J].

AMENTO, EP ;

EHSANI, N ;

PALMER, H ;

LIBBY, P .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1223-1230

[10] Cytotoxic T cells [J].

Andersen, Mads Hald ;

Schrama, David ;

Straten, Per thor ;

Becker, Juergen C. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (01) :32-41

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