Effect of semaglutide on weight loss and glycaemic control in patients with Prader-Willi Syndrome and type 2 diabetes

被引：5
作者：
Gimenez-Palop, Olga [1 ,2 ]
Romero, Ana [1 ]
Casamitjana, Laia [1 ,2 ]
Pareja, Rocio [1 ,2 ]
Rigla, Mercedes [1 ,2 ]
Caixas, Assumpta [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona, Hosp Univ Parc Tauli, Endocrinol & Nutr Dept, Corporacio Sanitaria Parc Tauli, Sabadell, Spain
[2] Univ Autonoma Barcelona, Dept Med, Bellaterra, Spain
来源：
ENDOCRINOLOGIA DIABETES Y NUTRICION | 2024年 / 71卷 / 02期
关键词：
Prader- Willi Syndrome; Diabetes mellitus; Semaglutide; Obesity; GLUCAGON-LIKE PEPTIDE-1; ADULTS;
D O I：
10.1016/j.endien.2023.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Prader-Willi Syndrome (PWS) is the most common genetic cause of obesity, occurring in approximately 1 in 15,000 newborns. It results from the lack of expression of genes on the paternal allele of the chromosomal region 15q-11q13 (65-75% due to type 1 or type 2 deletion). Individuals with PWS experience associated symptoms such as hypotonia, hyperphagia, and early-onset obesity (before 5 years of age). Around 20% of adults with PWS also develop type 2 diabetes. Previous studies have shown the beneficial effects of GLP1-RA medications, such as exenatide and liraglutide, in treating type 2 diabetes in PWS. However, there is limited information available on the use of semaglutide in PWS. This study aimed to evaluate the effects of semaglutide on weight loss and glycaemic control in four patients with PWS and type 2 diabetes associated with obesity. The patients were started on weekly subcutaneous progressive doses of semaglutide. (c) 2024 SEEN y SED. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：83 / 87
页数：5
相关论文
共 22 条
[1]   Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity [J].
Anandhakrishnan, Ananthi ;
Korbonits, Marta .
WORLD JOURNAL OF DIABETES, 2016, 7 (20) :572-598
[2]   Exenatide [J].
Barnett, A. .
EXPERT OPINION ON PHARMACOTHERAPY, 2007, 8 (15) :2593-2608
[3]   Prader-Willi Syndrome - Clinical Genetics, Diagnosis and Treatment Approaches: An Update [J].
Butler, Merlin G. ;
Miller, Jennifer L. ;
Forster, Janice L. .
CURRENT PEDIATRIC REVIEWS, 2019, 15 (04) :207-244
[4]   Prader-Willi syndrome [J].
Cassidy, Suzanne B. ;
Schwartz, Stuart ;
Miller, Jennifer L. ;
Driscoll, Daniel J. .
GENETICS IN MEDICINE, 2012, 14 (01) :10-26
[5]   Update on Diabetes Mellitus and Glucose Metabolism Alterations in Prader-Willi Syndrome [J].
Crino, Antonino ;
Grugni, Graziano .
CURRENT DIABETES REPORTS, 2020, 20 (02)
[6]   Endocrine Disorders in Children with Prader-Willi Syndrome - Data from 142 Children of the French Database [J].
Diene, G. ;
Mimoun, E. ;
Feigerlova, E. ;
Caula, S. ;
Molinas, C. ;
Grandjean, H. ;
Tauber, M. .
HORMONE RESEARCH IN PAEDIATRICS, 2010, 74 (02) :121-128
[7]   Liraglutide for Weight Management in Children and Adolescents With Prader-Willi Syndrome and Obesity [J].
Diene, Gwenaelle ;
Angulo, Moris ;
Hale, Paula M. ;
Jepsen, Cecilie H. ;
Hofman, Paul L. ;
Hokken-Koelega, Anita ;
Ramesh, Chethana ;
Turan, Serap ;
Tauber, Maithe .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, :4-12
[8]   Anti-Obesity Medication Use in Children and Adolescents with Prader-Willi Syndrome: Case Review and Literature Search [J].
Goldman, Victoria E. ;
Naguib, Monica N. ;
Vidmar, Alaina P. .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (19)
[9]   The Italian National Survey for Prader-Willi syndrome:: An epidemiologic study [J].
Grugni, Graziano ;
Crino, Antonino ;
Bosio, Laura ;
Corrias, Andrea ;
Cuttini, Marina ;
De Toni, Teresa ;
Di Battista, Eliana ;
Franzese, Adriana ;
Gargantini, Luigi ;
Greggio, Nella ;
Iughetti, Lorenzo ;
Livieri, Chiara ;
Naselli, Arturo ;
Pagano, Claudio ;
Pozzan, Giovanni ;
Ragusa, Letizia ;
Salvatoni, Alessandro ;
Trifiro, Giuliana ;
Beccaria, Luciano ;
Bellizzi, Maria ;
Bellone, Jaele ;
Brunani, Amelia ;
Cappa, Marco ;
Caselli, Gabriella ;
Cerioni, Valeria ;
Delvecchio, Maurizio ;
Giardino, Daniela ;
Ianni, Francesco ;
Memo, Luigi ;
Pilotta, Alba ;
Pomara, Cristoforo ;
Radetti, Giorgio ;
Sacco, Michele ;
Sanzari, Annarosa ;
Sartorio, Alessandro ;
Tonini, Giorgio ;
Vettor, Roberto ;
Zaglia, Federico ;
Chiumello, Giuseppe .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2008, 146A (07) :861-872
[10]   Psychopathological disorders in Prader-Willi syndrome [J].
Guinovart, Marti ;
Coronas, Ramon ;
Caixas, Assumpta .
ENDOCRINOLOGIA DIABETES Y NUTRICION, 2019, 66 (09) :579-587
123