LINE1 and its host: one cell's junk is another cell's treasure

被引：1

作者：

Martinez, John C. ^{[1
]}

Seluanov, Andrei ^{[1
,2
]}

Gorbunova, Vera ^{[1
,2
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[2] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14627 USA

来源：

EMBO JOURNAL | 2024年 / 43卷 / 17期

关键词：

D O I：

10.1038/s44318-024-00175-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 activation into mechanisms essential for cell function. New findings published by Mangiavacci et al (2024) in The EMBO Journal reveal the role of L1 RNA in stimulating osteogenic activity during bone repair in both mice and humans, highlighting a previously undescribed beneficial regulatory role for L1 activity. New findings show that expression of the LINE1 retrotransposon RNA stimulates bone repair in mice and humans.

引用

页码：3547 / 3549

页数：3

共 12 条

[1] Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
Barnsley, J.
Buckland, G.
Chan, P. E.
Ong, A.
Ramos, A. S.
Baxter, M.
Laskou, F.
Dennison, E. M.
Cooper, C.
Patel, Harnish P.
[J]. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2021, 33 (04) : 759 - 773
[2] eIF2α phosphorylation and the regulation of translation
Boye, Erik
Grallert, Beata
[J]. CURRENT GENETICS, 2020, 66 (02) : 293 - 297
[3] De Cecco M, 2019, NATURE, V572, pE5, DOI [10.1038/s41586-019-1350-9, 10.1038/s41586-018-0784-9]
[4] cGAS-STING drives ageing-related inflammation and neurodegeneration
Gulen, Muhammet F.
Samson, Natasha
Keller, Alexander
Schwabenland, Marius
Liu, Chong
Glueck, Selene
Thacker, Vivek V.
Favre, Lucie
Mangeat, Bastien
Kroese, Lona J.
Krimpenfort, Paul
Prinz, Marco
Ablasser, Andrea
[J]. NATURE, 2023, 620 (7973) : 374 - 380
[5] LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo
Jachowicz, Joanna W.
Bing, Xinyang
Pontabry, Julien
Boskovic, Ana
Rando, Oliver J.
Torres-Padilla, Maria-Elena
[J]. NATURE GENETICS, 2017, 49 (10) : 1502 - +
[6] LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response
Mangiavacchi, Arianna
Morelli, Gabriele
Reppe, Sjur
Saera-Vila, Alfonso
Liu, Peng
Eggerschwiler, Benjamin
Zhang, Huoming
Bensaddek, Dalila
Casanova, Elisa A.
Gomez, Carolina Medina
Prijatelj, Vid
Della Valle, Francesco
Atinbayeva, Nazerke
Belmonte, Juan Carlos Izpisua
Rivadeneira, Fernando
Cinelli, Paolo
Gautvik, Kaare Morten
Orlando, Valerio
[J]. EMBO JOURNAL, 2024, 43 (17) : 3587 - 3603
[7] LINE-1 regulates cortical development by acting as long non-coding RNAs
Mangoni, Damiano
Simi, Alessandro
Lau, Pierre
Armaos, Alexandros
Ansaloni, Federico
Codino, Azzurra
Damiani, Devid
Floreani, Lavinia
Di Carlo, Valerio
Vozzi, Diego
Persichetti, Francesca
Santoro, Claudio
Pandolfini, Luca
Tartaglia, Gian Gaetano
Sanges, Remo
Gustincich, Stefano
[J]. NATURE COMMUNICATIONS, 2023, 14 (01)
[8] Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
Mehdipour, Parinaz
Marhon, Sajid A.
Ettayebi, Ilias
Chakravarthy, Ankur
Hosseini, Amir
Wang, Yadong
de Castro, Fabiola Attie
Loo Yau, Helen
Ishak, Charles
Abelson, Sagi
O'Brien, Catherine A.
De Carvalho, Daniel D.
[J]. NATURE, 2020, 588 (7836) : 169 - +
[9] LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Simon, Matthew
Van Meter, Michael
Ablaeva, Julia
Ke, Zhonghe
Gonzalez, Raul S.
Taguchi, Taketo
De Cecco, Marco
Leonova, Katerina, I
Kogan, Valeria
Helfand, Stephen L.
Neretti, Nicola
Roichman, Asael
Cohen, Haim Y.
Meer, Margarita, V
Gladyshev, Vadim N.
Antoch, Marina P.
Gudkov, Andrei, V
Sedivy, John M.
Seluanov, Andrei
Gorbunova, Vera
[J]. CELL METABOLISM, 2019, 29 (04) : 871 - +
[10] LINE-1 retrotransposons in healthy and diseased human brain
Suarez, Nicole A.
Macia, Angela
Muotri, Alysson R.
[J]. DEVELOPMENTAL NEUROBIOLOGY, 2018, 78 (05) : 434 - 455

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