Preparation and characterization of cellulose nanocrystals reinforced poly (Vinyl alcohol) based hydrogels for drug delivery system

被引：4

作者：

Cho H. ^{[1
]}

Yoo W.-J. ^{[1
]}

Ahn J. ^{[1
]}

Chun S.-J. ^{[2
]}

Lee S.-Y. ^{[3
]}

Gwon J. ^{[1
]}

机构：

[1] Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science, Seoul

[2] Division of Wood Utilization, Department of forest Products, National Institute of Forest Science, Seoul

[3] Forest Biomaterials Research Center, National Institute of Forest Science, Jinju

来源：

Journal of the Korean Wood Science and Technology | 2020年 / 48卷 / 04期

关键词：

Cellulose nanocrystals (CNCs); Drug delivery system; Hydrogels; Poly (vinyl alcohol);

D O I：

10.5658/WOOD.2020.48.4.431

中图分类号：

学科分类号：

摘要：

Structural property of most hydrogels is soft, resulting in low mechanical performance that limits their usage in the biomedical applications. For overcoming the drawback, cellulose nanocrystals (CNCs) were adopted in this study. Effects of CNCs on characteristics and drug delivery performance of poly (vinyl alcohol) based hydrogels were explored. FT-IR results showed that the fabricated hydrogels had semi-IPN (semi-interpenetrating polymer network) by formation of acetal and aldehyde bridge. Water absorption and swelling ratio decreased with increasing CNCs content, and the hydrogels with CNCs showed better viscoelastic performance than the without CNCs. Also, CNCs mostly improved the ability of the hydrogel to absorb the drug and the sustainability of the drug release. These results demonstrated that incorporating CNCs into the hydrogel systems can be a good alternative to improve drug delivery performance and mechanical property of the hydrogels. © 2020, Korean Society of Wood Science Technology. All rights reserved.

引用

页码：431 / 449

页数：18

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