The Impact of Gut Microbiota Changes on Methotrexate-Induced Neurotoxicity in Developing Young Rats

被引：1

作者：

Chen, Yu-Chieh ^{[1
,2
,3
]}

Hou, Chih-Yao ^{[4
]}

Hsu, Mei-Hsin ^{[1
]}

Huang, Li-Tung ^{[1
]}

Hsiao, Chih-Cheng ^{[1
,2
,3
]}

Sheen, Jiunn-Ming ^{[1
,2
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan

[2] Chang Gung Univ, Dept Tradit Med, Taoyuan 333, Taiwan

[3] Natl Sun Yat sen Univ, Coll Med, Sch Med, Kaohsiung 804, Taiwan

[4] Natl Kaohsiung Univ Sci & Technol, Coll Hydrosphere, Dept Seafood Sci, Kaohsiung 807, Taiwan

来源：

BIOMEDICINES | 2024年 / 12卷 / 04期

关键词：

methotrexate; chemotherapy; cognitive impairment; gut microbiota; neurotoxicity; ACUTE LYMPHOBLASTIC-LEUKEMIA; HIGH-DOSE METHOTREXATE; INTRATHECAL METHOTREXATE; CHILDHOOD; COMMUNITIES; SEQUENCES; SURVIVORS; PROFILES; TOXICITY; IMMUNE;

D O I：

10.3390/biomedicines12040908

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methotrexate (MTX) is an essential part of therapy in the treatment of acute lymphoblastic leukemia (ALL) in children, and inferior intellectual outcomes have been reported in children who are leukemia survivors. Although several studies have demonstrated that the interaction between gut microbiota changes and the brain plays a vital role in the pathogenesis of chemotherapy-induced brain injury, preexisting studies on the effect of MTX on gut microbiota changes focused on gastrointestinal toxicity only. Based on our previous studies, which revealed that MTX treatment resulted in inferior neurocognitive function in developing young rats, we built a young rat model mimicking MTX treatment in a child ALL protocol, trying to investigate the interactions between the gut and brain in response to MTX treatment. We found an association between gut microbiota changes and neurogenesis/repair processes in response to MTX treatment, which suggest that MTX treatment results in gut dysbiosis, which is considered to be related to MTX neurotoxicity through an alteration in gut-brain axis communication.

引用

页数：19

共 71 条

[1] Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma [J].

Addona, Terri A. ;

Abbatiello, Susan E. ;

Schilling, Birgit ;

Skates, Steven J. ;

Mani, D. R. ;

Bunk, David M. ;

Spiegelman, Clifford H. ;

Zimmerman, Lisa J. ;

Ham, Amy-Joan L. ;

Keshishian, Hasmik ;

Hall, Steven C. ;

Allen, Simon ;

Blackman, Ronald K. ;

Borchers, Christoph H. ;

Buck, Charles ;

Cardasis, Helene L. ;

Cusack, Michael P. ;

Dodder, Nathan G. ;

Gibson, Bradford W. ;

Held, Jason M. ;

Hiltke, Tara ;

Jackson, Angela ;

Johansen, Eric B. ;

Kinsinger, Christopher R. ;

Li, Jing ;

Mesri, Mehdi ;

Neubert, Thomas A. ;

Niles, Richard K. ;

Pulsipher, Trenton C. ;

Ransohoff, David ;

Rodriguez, Henry ;

Rudnick, Paul A. ;

Smith, Derek ;

Tabb, David L. ;

Tegeler, Tony J. ;

Variyath, Asokan M. ;

Vega-Montoto, Lorenzo J. ;

Wahlander, Asa ;

Waldemarson, Sofia ;

Wang, Mu ;

Whiteaker, Jeffrey R. ;

Zhao, Lei ;

Anderson, N. Leigh ;

Fisher, Susan J. ;

Liebler, Daniel C. ;

Paulovich, Amanda G. ;

Regnier, Fred E. ;

Tempst, Paul ;

Carr, Steven A. .

NATURE BIOTECHNOLOGY, 2009, 27 (07) :633-U85

[2] Antibiotics, gut microbiota, and Alzheimer's disease [J].

Angelucci, Francesco ;

Cechova, Katerina ;

Amlerova, Jana ;

Hort, Jakub .

JOURNAL OF NEUROINFLAMMATION, 2019, 16 (1)

[3] Tax4Fun: predicting functional profiles from metagenomic 16S rRNA data [J].

Asshauer, Kathrin P. ;

Wemheuer, Bernd ;

Daniel, Rolf ;

Meinicke, Peter .

BIOINFORMATICS, 2015, 31 (17) :2882-2884

[4] Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina [J].

Barber, Casey N. ;

Goldschmidt, Hana L. ;

Lilley, Brendan ;

Bygrave, Alexei M. ;

Johnson, Richard C. ;

Huganir, Richard L. ;

Zack, Donald J. ;

Raben, Daniel M. .

JOURNAL OF LIPID RESEARCH, 2022, 63 (08)

[5]

Bokulich NA, 2013, NAT METHODS, V10, P57, DOI [10.1038/NMETH.2276, 10.1038/nmeth.2276]

[6] Microbiota and neurodevelopmental windows: implications for brain disorders [J].

Borre, Yuliya E. ;

O'Keeffe, Gerard W. ;

Clarke, Gerard ;

Stanton, Catherine ;

Dinan, Timothy G. ;

Cryan, John F. .

TRENDS IN MOLECULAR MEDICINE, 2014, 20 (09) :509-518

[7] QIIME allows analysis of high-throughput community sequencing data [J].

Caporaso, J. Gregory ;

Kuczynski, Justin ;

Stombaugh, Jesse ;

Bittinger, Kyle ;

Bushman, Frederic D. ;

Costello, Elizabeth K. ;

Fierer, Noah ;

Pena, Antonio Gonzalez ;

Goodrich, Julia K. ;

Gordon, Jeffrey I. ;

Huttley, Gavin A. ;

Kelley, Scott T. ;

Knights, Dan ;

Koenig, Jeremy E. ;

Ley, Ruth E. ;

Lozupone, Catherine A. ;

McDonald, Daniel ;

Muegge, Brian D. ;

Pirrung, Meg ;

Reeder, Jens ;

Sevinsky, Joel R. ;

Tumbaugh, Peter J. ;

Walters, William A. ;

Widmann, Jeremy ;

Yatsunenko, Tanya ;

Zaneveld, Jesse ;

Knight, Rob .

NATURE METHODS, 2010, 7 (05) :335-336

[8]

Cascella Marco, 2018, Recenti Progressi in Medicina, V109, P523, DOI 10.1701/3031.30289

[9] Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy [J].

Cerulla Torrente, Noemi ;

Navarro Pastor, Jose-Blas ;

de la Osa Chaparro, Nuria .

JOURNAL OF CANCER SURVIVORSHIP, 2020, 14 (04) :464-482

[10] Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease [J].

Chen, Szu-Ju ;

Chen, Chieh-Chang ;

Liao, Hsin-Yu ;

Lin, Ya-Ting ;

Wu, Yu-Wei ;

Liou, Jyh-Ming ;

Wu, Ming-Shiang ;

Kuo, Ching-Hua ;

Lin, Chin-Hsien .

NEUROLOGY, 2022, 98 (08) :E848-E858

← 1 2 3 4 5 6 7 8 →