Therapeutic potential of adipose-derived stem cell extracellular vesicles: from inflammation regulation to tissue repair

被引:3
作者
Zhou, Bohuai [1 ,3 ,4 ]
Chen, Qiuyu [1 ,2 ,3 ,4 ]
Zhang, Qiuwen [2 ,5 ]
Tian, Weidong [1 ,2 ,3 ,4 ]
Chen, Tian [1 ,2 ,3 ,6 ]
Liu, Zhi [1 ,2 ,3 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Engn Res Ctr Oral Translat Med, Minist Educ, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp Stomatol, Natl Engn Lab Oral Regenerat Med, Chengdu 610041, Peoples R China
[4] Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Chengdu 610041, Peoples R China
[5] Southwest Med Univ, Affiliated Stomatol Hosp, Luzhou 646000, Peoples R China
[6] Sichuan Univ, West China Hosp Stomatol, Dept Orthodont, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
Inflammation control; Tissue repair; Adipose-derived stem cell; Extracellular vesicles; Cell-free therapy; STROMAL CELLS; MYOCARDIAL-INFARCTION; B-LYMPHOCYTES; UP-REGULATION; BEIGE FAT; KAPPA-B; EXOSOMES; DISEASE; DELIVERY; OBESITY;
D O I
10.1186/s13287-024-03863-5
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Inflammation is a key pathological feature of many diseases, disrupting normal tissue structure and resulting in irreversible damage. Despite the need for effective inflammation control, current treatments, including stem cell therapies, remain insufficient. Recently, extracellular vesicles secreted by adipose-derived stem cells (ADSC-EVs) have garnered attention for their significant anti-inflammatory properties. As carriers of bioactive substances, these vesicles have demonstrated potent capabilities in modulating inflammation and promoting tissue repair in conditions such as rheumatoid arthritis, osteoarthritis, diabetes, cardiovascular diseases, stroke, and wound healing. Consequently, ADSC-EVs are emerging as promising alternatives to conventional ADSC-based therapies, offering advantages such as reduced risk of immune rejection, enhanced stability, and ease of storage and handling. However, the specific mechanisms by which ADSC-EVs regulate inflammation under pathological conditions are not fully understood. This review discusses the role of ADSC-EVs in inflammation control, their impact on disease prognosis, and their potential to promote tissue repair. Additionally, it provides insights into future clinical research focused on ADSC-EV therapies for inflammatory diseases, which overcome some limitations associated with cell-based therapies.
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页数:15
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共 134 条
[1]   Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].
Alvarez-Erviti, Lydia ;
Seow, Yiqi ;
Yin, HaiFang ;
Betts, Corinne ;
Lakhal, Samira ;
Wood, Matthew J. A. .
NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179
[2]   Exosomes from Adipose-Derived Stem Cells (ADSCs) Overexpressing miR-21 Promote Vascularization of Endothelial Cells [J].
An, Yang ;
Zhao, Jianfang ;
Nie, Fangfei ;
Qin, Zelian ;
Xue, Hongyu ;
Wang, Guanhuier ;
Li, Dong .
SCIENTIFIC REPORTS, 2019, 9 (1)
[3]   Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species [J].
Baglio, Serena Rubina ;
Rooijers, Koos ;
Koppers-Lalic, Danijela ;
Verweij, Frederik J. ;
Lanzon, M. Perez ;
Zini, Nicoletta ;
Naaijkens, Benno ;
Perut, Francesca ;
Niessen, Hans W. M. ;
Baldini, Nicola ;
Pegtel, D. Michiel .
STEM CELL RESEARCH & THERAPY, 2015, 6
[4]  
Barr TL, 2014, AGING DIS, V5, P292, DOI 10.14336/AD.2014.0500292
[5]   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis [J].
Berezikov, Eugene ;
van Tetering, Geert ;
Verheul, Mark ;
van de Belt, Jose ;
van Laake, Linda ;
Vos, Joost ;
Verloop, Robert ;
van de Wetering, Marc ;
Guryev, Victor ;
Takada, Shuji ;
van Zonneveld, Anton Jan ;
Mano, Hiroyuki ;
Plasterk, Ronald ;
Cuppen, Edwin .
GENOME RESEARCH, 2006, 16 (10) :1289-1298
[6]   miR-21-5p in extracellular vesicles obtained from adipose tissue-derived stromal cells facilitates tubular epithelial cell repair in acute kidney injury [J].
Bian, Zhixiang ;
Wang, Xiangxiang ;
Zhu, Rui ;
Chen, Shunjie .
CYTOTHERAPY, 2023, 25 (03) :310-322
[7]  
Budoni M, 2013, CELL TRANSPLANT, V22, P369, DOI 10.3727/096368911X582769
[8]   Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure [J].
Carriere, Audrey ;
Jeanson, Yannick ;
Berger-Mueller, Sandra ;
Andre, Mireille ;
Chenouard, Vanessa ;
Arnaud, Emmanuelle ;
Barreau, Corinne ;
Walther, Romy ;
Galinier, Anne ;
Wdziekonski, Brigitte ;
Villageois, Phi ;
Louche, Katie ;
Collas, Philippe ;
Moro, Cedric ;
Dani, Christian ;
Villarroya, Francesc ;
Casteilla, Louis .
DIABETES, 2014, 63 (10) :3253-3265
[9]   Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis [J].
Cavallo, Carola ;
Merli, Giulia ;
Borzi, Rosa Maria ;
Zini, Nicoletta ;
D'Adamo, Stefania ;
Guescini, Michele ;
Grigolo, Brunella ;
Di Martino, Alessandro ;
Santi, Spartaco ;
Filardo, Giuseppe .
SCIENTIFIC REPORTS, 2021, 11 (01)
[10]   Stem cells rescue cardiomyopathy induced by P-gingivalis-LPS via miR-181b [J].
Chen, Tung-Sheng ;
Battsengel, Sarnai ;
Kuo, Chia-Hua ;
Pan, Lung-Fa ;
Lin, Yueh-Min ;
Yao, Chun-Hsu ;
Chen, Yueh-Sheng ;
Lin, Feng-Huei ;
Kuo, Wei-Wen ;
Huang, Chih-Yang .
JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (08) :5869-5876