The Role of Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer

被引：11

作者：

Kim, Kyounghyun ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Coll Med, Dept Pharmacol & Toxicol, Little Rock, AR 72225 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 07期

关键词：

endocrine disrupting chemicals; environmental toxicants; aryl hydrocarbon receptor; pancreas; pancreatitis; pancreatic injury; pancreatic cancer; POLYCYCLIC AROMATIC-HYDROCARBONS; PERSISTENT ORGANIC POLLUTANTS; STIMULATED INSULIN-SECRETION; DIABETES TYPE-1 DEVELOPMENT; DIOXIN-LIKE COMPOUNDS; BISPHENOL-A; SERUM CONCENTRATIONS; CIGARETTE-SMOKE; HEAVY-METALS; HUMAN HEALTH;

D O I：

10.3390/ijms25073818

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aryl hydrocarbon receptor (AHR) serves as a ligand-activated transcription factor crucial for regulating fundamental cellular and molecular processes, such as xenobiotic metabolism, immune responses, and cancer development. Notably, a spectrum of endocrine-disrupting chemicals (EDCs) act as agonists or antagonists of AHR, leading to the dysregulation of pivotal cellular and molecular processes and endocrine system disruption. Accumulating evidence suggests a correlation between EDC exposure and the onset of diverse pancreatic diseases, including diabetes, pancreatitis, and pancreatic cancer. Despite this association, the mechanistic role of AHR as a linchpin molecule in EDC exposure-related pathogenesis of pancreatic diseases and cancer remains unexplored. This review comprehensively examines the involvement of AHR in EDC exposure-mediated regulation of pancreatic pathogenesis, emphasizing AHR as a potential therapeutic target for the pathogenesis of pancreatic diseases and cancer.

引用

页数：19

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