Recent Progress in N-Iodosuccinimide (NIS)-Mediated Iodination Reactions

Organoiodine compounds belong to a very important class of functional molecules and their synthesis research is of great significance. Given the advantages of N-iodosuccinimide (NIS) with high reactivity, cheap and easy to get and environmental friendliness, it has always been the preferred iodine reagent for iodization, and in recent years, the preparation of organic iodine compounds by iodization reaction with NIS has made great progress, which has received considerable interest. To this end, the research progress is summarized, including the C-H iodization of NIS and aromatics/terminal alkynes, iodine difunctionalization between NIS and unsaturated compounds with nucleophiles, and cascade iodocyclization between NIS and unsaturated compounds.