Realization of cellomics to dive into the whole-body or whole-organ cell cloud

被引：2

作者：

Mitani, Tomoki T. ^{[1
,2
,3
]}

Susaki, Etsuo A. ^{[1
,4
,5
]}

Matsumoto, Katsuhiko ^{[1
,6
]}

Ueda, Hiroki R. ^{[1
,6
]}

机构：

[1] RIKEN, Ctr Biosyst Dynam Res, Lab Synthet Biol, Osaka, Japan

[2] Osaka Univ, Grad Sch Med, Dept Syst Biol, Osaka, Japan

[3] Osaka Univ, Grad Sch Med, Dept Neurol, Osaka, Japan

[4] Juntendo Univ, Grad Sch Med, Dept Biochem & Syst Biomed, Tokyo, Japan

[5] Juntendo Univ, Nakatani Biomed Spatial Hub, Grad Sch Med, Tokyo, Japan

[6] Univ Tokyo, Grad Sch Med, Dept Syst Pharmacol, Tokyo, Japan

来源：

NATURE METHODS | 2024年 / 21卷 / 07期

关键词：

COMMON COORDINATE FRAMEWORK; LIGHT-SHEET MICROSCOPY; MOUSE-BRAIN;

D O I：

10.1038/s41592-024-02307-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissues, organs and organ systems are composed of interacting cells (the cellome). We discuss the emergence of an omics approach that we refer to as cellomics. It enables cellome-wide analysis in whole-organ or whole-body specimens, based on advanced three-dimensional imaging and image analysis technology. We think that cellomics will pave the way for the incorporation of cellular, intercellular and spatial information across millions of cells in our body.

引用

页码：1138 / 1142

页数：5

共 26 条

[1] Cellomics approach for high-throughput functional annotation of Caenorhabditis elegans neural network [J].

Aoki, Wataru ;

Matsukura, Hidenori ;

Yamauchi, Yuji ;

Yokoyama, Haruki ;

Hasegawa, Koichi ;

Shinya, Ryoji ;

Ueda, Mitsuyoshi .

SCIENTIFIC REPORTS, 2018, 8

[2]

Bubnis G., 2019, PREPRINT, DOI DOI 10.48550/ARXIV.1903.09227

[3] Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution [J].

Chakraborty, Tonmoy ;

Driscoll, Meghan K. ;

Jeffery, Elise ;

Murphy, Malea M. ;

Roudot, Philippe ;

Chang, Bo-Jui ;

Vora, Saumya ;

Wong, Wen Mai ;

Nielson, Cara D. ;

Zhang, Hua ;

Zhemkov, Vladimir ;

Hiremath, Chitkale ;

De la Cruz, Estanislao Daniel ;

Yi, Yating ;

Bezprozvanny, Ilya ;

Zhao, Hu ;

Tomer, Raju ;

Heintzmann, Rainer ;

Meeks, Julian P. ;

Marciano, Denise K. ;

Morrison, Sean J. ;

Danuser, Gaudenz ;

Dean, Kevin M. ;

Fiolka, Reto .

NATURE METHODS, 2019, 16 (11) :1109-+

[4] Application of tissue engineering to the immune system: development of artificial lymph nodes [J].

Cupedo, Tom ;

Stroock, Abraham ;

Coles, Mark .

FRONTIERS IN IMMUNOLOGY, 2012, 3

[5] A platform for brain-wide imaging and reconstruction of individual neurons [J].

Economon, Michael N. ;

Clack, Nathan G. ;

Levis, Luke D. ;

Gerfen, Charles R. ;

Svoboda, Karel ;

Myers, Eugene W. ;

Chandrashekar, Jayaram .

ELIFE, 2016, 5

[6] Molecular evolution of FOXP2, a gene involved in speech and language [J].

Enard, W ;

Przeworski, M ;

Fisher, SE ;

Lai, CSL ;

Wiebe, V ;

Kitano, T ;

Monaco, AP ;

Pääbo, S .

NATURE, 2002, 418 (6900) :869-872

[7]

Glaser Adam, 2025, bioRxiv, DOI 10.1101/2023.06.08.544277

[8] A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues [J].

Glaser, Adam K. ;

Bishop, Kevin W. ;

Barner, Lindsey A. ;

Susaki, Etsuo A. ;

Kubota, Shimpei I. ;

Gao, Gan ;

Serafin, Robert B. ;

Balaram, Pooja ;

Turschak, Emily ;

Nicovich, Philip R. ;

Lai, Hoyin ;

Lucas, Luciano A. G. ;

Yi, Yating ;

Nichols, Eva K. ;

Huang, Hongyi ;

Reder, Nicholas P. ;

Wilson, Jasmine J. ;

Sivakumar, Ramya ;

Shamskhou, Elya ;

Stoltzfus, Caleb R. ;

Wei, Xing ;

Hempton, Andrew K. ;

Pende, Marko ;

Murawala, Prayag ;

Dodt, Hans-Ulrich ;

Imaizumi, Takato ;

Shendure, Jay ;

Beliveau, Brian J. ;

Gerner, Michael Y. ;

Xin, Li ;

Zhao, Hu ;

True, Lawrence D. ;

Reid, R. Clay ;

Chandrashekar, Jayaram ;

Ueda, Hiroki R. ;

Svoboda, Karel ;

Liu, Jonathan T. C. .

NATURE METHODS, 2022, 19 (05) :613-+

[9] Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens [J].

Glaser, Adam K. ;

Reder, Nicholas P. ;

Chen, Ye ;

McCarty, Erin F. ;

Yin, Chengbo ;

Wei, Linpeng ;

Wang, Yu ;

True, Lawrence D. ;

Liu, Jonathan T. C. .

NATURE BIOMEDICAL ENGINEERING, 2017, 1 (07)

[10] Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging [J].

Goltsev, Yury ;

Samusik, Nikolay ;

Kennedy-Darling, Julia ;

Bhate, Salil ;

Hale, Matthew ;

Vazquez, Gustavo ;

Black, Sarah ;

Nolan, Garry P. .

CELL, 2018, 174 (04) :968-+

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