From homeostasis to defense: Exploring the role of selective autophagy in innate immunity and viral infections

被引：1

作者：

Huang, Mengyao ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Yang, Yang ^{[1
,2
]}

Shao, Wenhua ^{[1
,2
]}

Wang, Jiali ^{[1
,2
]}

Cao, Weijun ^{[1
,2
]}

Zhu, Zixiang ^{[1
,2
]}

Yang, Fan ^{[1
,2
]}

Zheng, Haixue ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, Lanzhou Univ, Lanzhou Vet Res Inst, Coll Vet Med,State Key Lab Anim Dis Control & Prev, Lanzhou 730000, Peoples R China

[2] Gansu Prov Res Ctr Basic Disciplines Pathogen Biol, Lanzhou 730046, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2024年 / 262卷

关键词：

Autophagy; Selective autophagy; Cargo receptor; Innate immunity; Viral infection; RIG-I; DEGRADATION; PROTEIN; INFLAMMATION; REPLICATION; OPTINEURIN; COVID-19; TOLLIP; OPTN;

D O I：

10.1016/j.clim.2024.110169

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The process of autophagy, a conservative evolutionary mechanism, is responsible for the removal of surplus and undesirable cytoplasmic components, thereby ensuring cellular homeostasis. Autophagy exhibits a remarkable level of selectivity by employing a multitude of cargo receptors that possess the ability to bind both ubiquitinated cargoes and autophagosomes. In the context of viral infections, selective autophagy plays a crucial role in regulating the innate immune system. Notably, numerous viruses have developed strategies to counteract, evade, or exploit the antiviral effects of selective autophagy. This review encompasses the latest research progress of selective autophagy in regulating innate immunity and virus infectious.

引用

页数：9