Cellular senescence molecules expression in type 2 diabetes mellitus: CDKN2A, CDKN2B, and lncRNA ANRIL

被引：1
|
作者：
Anaraki, Soheila [1 ]
Kheirandish, Masoumeh [2 ]
Mousavi, Pegah [3 ]
Tamandegani, Atefe Ebrahimi [1 ]
Mohammadi, Samane [1 ]
Shekari, Mohammad [1 ]
机构：
[1] Hormozgan Univ Med Sci, Fac Med, Dept Med Genet, Bandar Abbas 7919915519, Iran
[2] Hormozgan Univ Med Sci, Endocrinol & Metab Res Ctr, Bandar Abbas, Iran
[3] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Mol Med Res Ctr, Bandar Abbas, Iran
来源：
GENE | 2024年 / 911卷
关键词：
Biomarker; Long noncoding RNA; Cyclin-dependent kinase inhibitor 2A /2B; CDKN2B-AS1; Real-time PCR; Peripheral blood mononuclear cells; INFLAMMATION; DISEASE; CELLS;
D O I：
10.1016/j.gene.2024.148319
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aims: Cellular senescence in type 2 diabetes mellitus (T2DM) has received widespread attention. However, the cellular senescence molecules involved in T2DM are unclear. Furthermore, there are no consistent biomarkers for cellular senescence in T2DM. Therefore, this study aimed to identify cellular senescence molecules in T2DM and investigate their expression in peripheral blood mononuclear cells of individuals with T2DM. Methods: Patients with T2DM (n = 40) and healthy controls (n = 40) were enrolled. We used different databases to identify cellular senescence molecules in T2DM and confirmed the obtained genes and lncRNA using real-time PCR. Results: Bioinformatics analysis indicated that CDKN2A and CDKN2B genes, and long noncoding RNA ANRIL are the most effective cellular senescence molecules in T2DM. Furthermore, CDKN2A and ANRIL expression decreased in individuals with T2DM. Conclusions: Cellular senescence may have a protective effect against T2DM. In addition, the cellular senescence molecules CDKN2A and ANRIL may be potential biomarkers of cellular senescence in T2DM.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Molecular genetic analysis of oligodendroglial tumors for alterations of the CDKN2A and CDKN2B tumor suppressor genes
    Wolter, M
    Reifenberger, J
    Ichimura, K
    Schmidt, EE
    Collins, VP
    Reifenberger, G
    BRAIN PATHOLOGY, 2000, 10 (04) : 570 - 571
  • [22] Alterations of the cyclin-dependent kinase inhibitor genes CDKN2A, CDKN2B and CDKN2C in atypical and anaplastic meningiomas
    Boström, J
    Meyer-Puttlitz, B
    Blaschke, B
    Wolter, M
    Weber, RG
    Lichter, P
    Collins, VP
    Reifenberger, G
    BRAIN PATHOLOGY, 2000, 10 (04) : 742 - 742
  • [23] CDKN2A, CDKN2B and p14ARF are frequently and differentially methylated in ependymal tumours
    Rousseau, E
    Ruchoux, MM
    Scaravilli, F
    Chapon, F
    Vinchon, M
    De Smet, C
    Godfraind, C
    Vikkula, M
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2003, 29 (06) : 574 - 583
  • [24] Evaluation of the role of CDKN2B gene in type 2 diabetes mellitus and hypertension in ethnic Saudi Arabs
    AlRasheed, Maha Meshal
    SAUDI PHARMACEUTICAL JOURNAL, 2018, 26 (08) : 1199 - 1203
  • [25] Islet biology, the CDKN2A/B locus and type 2 diabetes risk
    Yahui Kong
    Rohit B. Sharma
    Benjamin U. Nwosu
    Laura C. Alonso
    Diabetologia, 2016, 59 : 1579 - 1593
  • [26] Islet biology, the CDKN2A/B locus and type 2 diabetes risk
    Kong, Yahui
    Sharma, Rohit B.
    Nwosu, Benjamin U.
    Alonso, Laura C.
    DIABETOLOGIA, 2016, 59 (08) : 1579 - 1593
  • [27] Structural and functional analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in neuroblastoma
    Iolascon, A
    Giordani, L
    Moretti, A
    Tonini, GP
    Lo Cunsolo, C
    Mastropietro, S
    Borriello, A
    Della Ragione, F
    PEDIATRIC RESEARCH, 1998, 43 (01) : 139 - 144
  • [28] Structural and Functional Analysis of Cyclin-Dependent Kinase Inhibitor Genes(CDKN2A, CDKN2B, and CDKN2C) in Neuroblastoma
    Achille Iolascon
    Lucia Giordani
    Arcangela Moretti
    Gian Paolo Tonini
    Crocefissa Lo Cunsolo
    Silvia Mastropietro
    Adriana Borriello
    Fulvio Della Ragione
    Pediatric Research, 1998, 43 : 139 - 144
  • [29] Identification and mapping of swine cyclin-dependent kinase inhibitor CDKN2A and CDKN2B exon 2 sequences
    Le Chalony, C
    Hayes, H
    Frelat, G
    Geffrotin, C
    CYTOGENETICS AND CELL GENETICS, 2000, 88 (3-4): : 240 - 243
  • [30] Concomitant Deletions of IKZF1, CDKN2A, and CDKN2B in Pediatric B-Acute Lymphoblastic Leukemia
    Honebrink, Theodore
    Peterson, Jess
    Yohe, Sophia
    Thyagarajan, Bharat
    Peterson, Randolph
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2012, 138 (03) : 472 - 472
12345