Characterization of carotid plaques using chemical exchange saturation transfer imaging

被引：0

作者：

Kanematsu, Yasuhisa ^{[1
]}

Kanazawa, Yuki ^{[2
]}

Shimada, Kenji ^{[1
]}

Korai, Masaaki ^{[1
]}

Miyamoto, Takeshi ^{[1
]}

Sogabe, Shu ^{[1
]}

Ishihara, Manabu ^{[1
]}

Yamaguchi, Izumi ^{[1
]}

Oya, Takeshi ^{[3
]}

Yamamoto, Nobuaki ^{[4
]}

Yamamoto, Yuki ^{[4
]}

Miyoshi, Mitsuharu ^{[5
]}

Harada, Masafumi ^{[6
]}

Takagi, Yasushi ^{[1
]}

机构：

[1] Tokushima Univ, Grad Sch Biomed Sci, Dept Neurosurg, 3-18-15 Kuramoto-Cho, Tokushima 7708503, Japan

[2] Tokushima Univ, Dept Med Imaging & Phys, Grad Sch Biomed Sci, Tokushima, Japan

[3] Tokushima Univ, Grad Sch Biomed Sci, Dept Mol Pathol, Tokushima, Japan

[4] Tokushima Univ, Grad Sch Biomed Sci, Dept Clin Neurosci, Tokushima, Japan

[5] GE HealthCare, Global MR Clin Solut & Res Collaborat, Hino, Japan

[6] Tokushima Univ, Grad Sch Biomed Sci, Dept Radiol, Tokushima, Japan

来源：

NEURORADIOLOGY | 2024年 / 66卷 / 09期

关键词：

CEST-MRI; APT imaging; Preoperative assessment; Carotid plaque; Intraplaque hemorrhage; HIGH-RISK; VIVO; ATHEROSCLEROSIS; CLASSIFICATION; ENDARTERECTOMY; PROTEINS;

D O I：

10.1007/s00234-024-03401-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

PurposeThe preoperative assessment of carotid plaques is necessary to render revascularization safe and effective. The aim of this study is to evaluate the usefulness of chemical exchange saturation transfer (CEST)-MRI, particularly amide proton transfer (APT) imaging as a preoperative carotid plaque diagnostic tool. MethodsWe recorded the APT signal intensity on concentration maps of 34 patients scheduled for carotid endarterectomy. Plaques were categorized into group A (APT signal intensity >= 1.90 E-04; n = 12) and group B (APT signal intensity < 1.90 E-04; n = 22). Excised plaques were subjected to histopathological assessment and, using the classification promulgated by the American Heart Association, they were classified as intraplaque hemorrhage-positive [type VI-positive (tVI+)] and -negative [no intraplaque hemorrhage (tVI-)]. ResultsOf the 34 patients, 22 (64.7%) harbored tVI+- and 12 (35.3%) had tVI- plaques. The median APT signals were significantly higher in tVI+- than tIVI- patients (2.43 E-04 (IQR = 0.98-4.00 E-04) vs 0.54 E-04 (IQR = 0.14-1.09 E-04), p < .001). Histopathologically, the number of patients with tVI+ plaques was significantly greater in group A (100%, n = 12) than group B (45%, n = 22) (p < .01). The number of symptomatic patients or asymptomatic patients with worsening stenosis was also significantly greater in group A than group B (75% vs 36%, p < .01). ConclusionIn unstable plaques with intraplaque hemorrhage and in patients with symptoms or progressive stenosis, the ATP signals were significantly elevated. CEST-MRI studies has the potential for the preoperative assessment of the plaques' characteristics.

引用

页码：1617 / 1624

页数：8

共 23 条

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