With the advancement of semiconductor industry technology, the entire field of electronic information and smart devices has an increasingly urgent requirement of small size, low power, high integration, and excellent performance of semiconductor devices. Two-dimensional (2D) layered semiconductor materials have shown a geometric structure with atomic thickness, and due to the size effects and quantum effects, pre-sent unique electrical and optical properties. In view of the excellent performance of mobility, switching ratio, and photoelectric response, 2D material-based electronic devices have shown promising application prospects in many fields, including high-performance chips, photodetectors, sensors and flexible electronic devices. Traditional sensors have shown low selectivity, high power, and low sensitivity requirements, which limits their further applications. Therefore, developing low-cost, high-stability, low-detection limit, and intelligent miniature sensors is one of the key directions in this field. In recent years, some new materials and new device structures have been applied into various sensors, including boron nitride (h-BN), black phosphorus (BP) and 2D transition metal chalcogenides (TMDs), which significantly improved the performance of sensors. However, 2D material-based sensors are difficult to prepare and the material cost is high, which limits the large-scale application of 2D material-based sensors in practical field. Meanwhile the stability and repeatability of the sensor need to be further improved. In this review, the latest developments in many aspects of TMDs-based electronic devices (including gas sensors, glucose sensors and pH sensors) are summarized from the aspect of sensitive materials, sensing performance, and sensitivity. In addition, the performance of 2D mate-rial-based sensors and their application prospects are discussed. The performance and structure of different 2D material-based devices are analyzed. Moreover, a series of methods to improve device performance and broaden the applications range of device are summarized, including doping, modification, and modification of the surface of 2D materials. In summary, this review provides a reference for the preparation of sensors with high stability and high sensitivity. © 2022, Materials Review Magazine. All right reserved.