Immune cell landscapes are associated with high-grade serous ovarian cancer survival

被引：0

作者：

Zhang, Guoan ^{[1
]}

Zhang, Yan ^{[1
]}

Zhang, Jingjing ^{[1
]}

Yang, Xiaohui ^{[2
]}

Sun, Wenjie ^{[3
]}

Liu, Ying ^{[1
]}

Liu, Yingfu ^{[2
,3
]}

机构：

[1] Cangzhou Med Coll, Sci & Technol Expt Ctr, Cangzhou 061001, Peoples R China

[2] Cangzhou Med Coll, Cangzhou Nanobody Technol Innovat Ctr, Cangzhou 061001, Peoples R China

[3] Univ Nanobody Applicat Technol Res & Dev Ctr Hebei, Cangzhou 061001, Hebei, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

High-grade serous ovarian cancer; T cell activation; Overall survival; Macrophage; Cell ratios; EXPRESSION;

D O I：

10.1038/s41598-024-67213-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlying chemotherapy resistance in HGSOC. Transcriptome deconvolution was performed to address cellular heterogeneity. Kaplan-Meier survival curves were plotted to illustrate the outcomes of patients with varying cellular abundances. The association between gene expression and chemotherapy response was tested. After adjusting for surgery status and grading, several cell states exhibited a significant correlation with patient survival. Cell states can organize into carcinoma ecotypes (CE). CE9 and CE10 were proinflammatory, characterized by higher immunoreactivity, and were associated with favorable survival outcomes. Ratios of cell states and ecotypes had better prognostic abilities than a single cell state or ecotype. A total of 1265 differentially expressed genes were identified between samples with high and low levels of C9 or CE10. These genes were partitioned into three co-expressed modules, which were associated with tumor cells and immune cells. Pogz was identified to be linked with immune cell genes and the chemotherapy response of paclitaxel. Collectively, the survival of HGSOC patients is correlated with specific cell states and ecotypes.

引用

页数：10

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