Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity

被引：7

作者：

Yen, Pham Hai ^{[1
]}

Tai, Bui Huu ^{[1
,2
]}

Hang, Dan Thi Thuy ^{[1
]}

Lam, Le Doan Tung ^{[2
]}

Dung, Duong Thi ^{[1
]}

Trang, Do Thi ^{[1
]}

Yen, Duong Thi Hai ^{[1
]}

Hoang, Nguyen Huy ^{[1
]}

Huong, Phan Thi Thanh ^{[1
]}

Dung, Nguyen Viet ^{[1
]}

Bang, Ngo Anh ^{[1
]}

Duy, Nguyen Duc ^{[3
]}

Kiem, Phan Van ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[3] Ctr High Technol Res & Dev, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

来源：

RSC ADVANCES | 2024年 / 14卷 / 17期

关键词：

ACANTHOPANAX-SENTICOSUS HARMS; SAPONINS; CIWUJIA; LEAVES;

D O I：

10.1039/d4ra01483a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, seven new pentacyclic triterpene glycosides, named dendrocinaosides A-G (1-7), and six known ones (8-13) were isolated from the whole plants of Dendrobium officinale. Their structures were determined by analyses of HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-4, 8, and 9 potentially inhibited alpha-glucosidase and alpha-amylase activities with the IC50 values ranging from 31.3 +/- 2.2 to 42.4 +/- 2.5 mu M for anti alpha-glucosidase and from 36.5 +/- 1.8 to 56.4 +/- 2.0 mu M for anti alpha-amylase activities, respectively, which were lower than that of the positive control, acarbose, showing IC50 values of 47.1 +/- 1.4 mu M for anti alpha-glucosidase and 145.7 +/- 2.2 mu M for anti alpha-amylase.

引用

页码：12147 / 12157

页数：11

共 24 条

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