A pair of new enantiomeric alkaloids from Tinospora sinensis

被引：3

作者：

Liang, Yan ^{[1
]}

Guo, Shaobo ^{[1
]}

Guo, Yonghua ^{[1
]}

Xu, Chang ^{[1
]}

Wang, Guiyang ^{[3
]}

Zhang, Wei ^{[1
,2
]}

Liu, Bin ^{[1
,2
]}

机构：

[1] Beijing Univ Chinese Med, Beijing, Peoples R China

[2] State Adm Tradit Chinese Med Peoples Republ China, Key Res Lab Exploring Effect Subst Class & Famous, Beijing 102488, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2024年 / 60卷

关键词：

Enantiomeric alkaloid; Tinospora sinensis (Lour.) Merr; Anti-inflammatory activity; Chemical constituent; CHEMICAL-CONSTITUENTS;

D O I：

10.1016/j.phytol.2024.02.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A pair of new enantiomeric alkaloids (+)-1 and (-)-1, along with eight known compounds (2-9) were isolated from the stem of Tinospora sinensis (Lour.) Merr. Their structures were elucidated on the basis of comprehensive analysis of HRESIMS and NMR spectroscopic data as well as CD spectroscopy methods. In addition, the isolated compounds were evaluated for their anti-inflammatory activity. Compounds (+)-1 and (-)-1 inhibited the release of NO from RAW264.7 cells induced by LPS with the IC50 values of 0.34 +/- 0.02 mu M and 3.37 +/- 0.24 mu M, respectively.

引用

页码：179 / 183

页数：5

共 26 条

[1] Immunomodulatory effect of an isolated fraction from Tinospora crispa on intracellular expression of INF-γ, IL-6 and IL-8 [J].