Quercetin and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities

被引：0

作者：

Kurt A.H. ^{[1
]}

Olutas E.B. ^{[2
]}

Avcioglu F. ^{[3
]}

Karakuş H. ^{[4
]}

Sungur M.A. ^{[5
]}

Oztabag C.K. ^{[6
]}

Yıldırım M. ^{[2
]}

机构：

[1] Department of Medicinal Pharmacology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu

[2] Department of Chemistry, Faculty of Arts and Sciences, Bolu Abant Izzet Baysal University, Bolu

[3] Department of Medical Microbiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu

[4] Technology Transfer Application and Research Center, Bolu Abant Izzet Baysal University, Bolu

[5] Department of Biostatistics and Medical Informatics, Faculty of Medicine, Duzce University, Duzce

[6] Department of Interdisciplinary Neuroscience, Graduate Education Institute, Bolu Abant Izzet Baysal University, Bolu

来源：

Beilstein Journal of Nanotechnology | 2023年 / 14卷

关键词：

Ag NPs; anticancer and antibacterial effects; caffeic acid; chitosan; one-pot synthesis; quercetin; U-118 MG and ARPE-19 cells;

D O I：

10.3762/BJNANO.14.31

中图分类号：

学科分类号：

摘要：

The presented study comprises the one-pot synthesis and the characterization of quercetin and caffeic acid-functionalized chitosancapped colloidal silver nanoparticles (Ch/Q and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q and Ch/CA-Ag NPs has been confirmed by ultraviolet–visible (UV–vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q and Ch/CA-Ag NPs, respectively. The formation of a chitosan shell comprising quercetin and caffeic acid, which surround the colloidal core Ag NPs, was confirmed by UV–vis, and FTIR analyses, and monitored by TEM microscopy. The size of nanoparticles has been determined as 11.2 and 10.3 nm for Ch/Q and Ch/CA-Ag, respectively. The anticancer activity of Ch/Q and Ch/CA-Ag NPs has been evaluated against U-118 MG (human glioblastoma) and ARPE-19 (human retinal pigment epithelium) cells. Both NPs showed anticancer activity, but Ch/Q-Ag NPs seemed to be more effective on cancer cell lines (U-118 MG) in comparison to healthy ones (ARPE-19). Furthermore, the antibacterial activity of Ch/Q and Ch/CA-Ag NPs against Gram-negative (P. aeruginosa and E. coli) and Gram-positive (S. aureus and S. epidermidis) bacteria was determined, and dose-dependent antibacterial effects were found. © 2023 Kurt et al.; licensee Beilstein-Institut. License and terms: see end of document.

引用

页码：362 / 376

页数：14